In vitro evaluation of ampicillin-gentamicin interactions
Date
1989
Authors
Van der Bijl P.
Seifart H.I.
Nat R.
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Ampicillin at a concentration of 100 μg/mL was combined in vitro with either gentamicin 10 μg/mL in serum, 0.01 mol/L phosphate-buffered saline at 37°C, or water at room temperature (25°C). At these concentrations, which represent the peak prophylactic serum concentrations likely to be achieved by a 70-kg person after parenteral administration of 1.5 mg/kg gentamicin and 2 g of ampicillin, no clinically significant inactivating effects of these antibiotics on each other were observed over a period of six hours.
Description
Keywords
ampicillin, gentamicin, drug mixture, human, in vitro study, intravenous drug administration, oral surgery, priority journal, surgery, Ampicillin, Chromatography, High Pressure Liquid, Drug Interactions, Gentamicins, Human, In Vitro, Temperature
Citation
Journal of Oral and Maxillofacial Surgery
47
5
47
5