In vitro evaluation of ampicillin-gentamicin interactions

Van der Bijl P. ; Seifart H.I. ; Nat R. (1989)

Article

Ampicillin at a concentration of 100 μg/mL was combined in vitro with either gentamicin 10 μg/mL in serum, 0.01 mol/L phosphate-buffered saline at 37°C, or water at room temperature (25°C). At these concentrations, which represent the peak prophylactic serum concentrations likely to be achieved by a 70-kg person after parenteral administration of 1.5 mg/kg gentamicin and 2 g of ampicillin, no clinically significant inactivating effects of these antibiotics on each other were observed over a period of six hours.

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