Nutritional supplements for people being treated for active tuberculosis

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Show simple item record Abba, K. Sudarsanam, T. D. Grobler, L. Volmink, J. 2011-05-15T16:01:27Z 2011-05-15T16:01:27Z 2008
dc.identifier.citation Cochrane Database of Systematic Reviews
dc.identifier.citation 4
dc.identifier.issn 1469493X
dc.identifier.other 10.1002/14651858.CD006086.pub2
dc.description.abstract Background: Tuberculosis is a serious infection affecting mainly the lungs. It may contribute to nutritional deficiencies which in turn may delay recovery by depressing immune functions. Nutritional supplements might therefore promote recovery in people being treated for tuberculosis. Objectives: To assess the provision of oral nutritional supplements to promote the recovery of people being treated with antituberculous drug therapy for active tuberculosis. Search strategy: We searched the Cochrane Infectious Disease Group Specialized Register (June 2008), CENTRAL (The Cochrane Library 2008, Issue 2), MEDLINE (June 2008), EMBASE (June 2008), LILACS (June 2008), mRCT (June 2008), the Indian Journal of Tuberculosis (1983 to June 2008), and checked the reference lists of all included studies. Selection criteria: Randomized controlled trials comparing any oral nutritional supplement given for at least four weeks with no nutritional intervention, placebo, or dietary advice only for people being treated for active tuberculosis. Data collection and analysis: Two authors independently selected trials, extracted data, and assessed risk of bias. We calculated risk ratios (RR) for dichotomous variables and mean differences (MD) for continuous variables, with 95% confidence intervals (CI). We pooled data from trials with similar interventions and outcomes. Main results: Twelve trials (3393 participants) were included. Five trials had adequate allocation concealment. Interventions included a high energy supplement, high cholesterol diet, vitamin D, vitamin A, zinc, arginine, multiple micronutrient supplements, combined multiple micronutrient supplements and zinc, combined vitamin A and zinc, and combined vitamin A and selenium. The following supplements were associated with increased body weight at follow up: high energy supplements (MD 1.73 kg, 95% CI 0.81 to 2.65; 34 participants, 1 trial); multiple micronutrients plus additional zinc (MD 2.37 kg, 95% CI 2.21 to 2.53; 192 participants, 1 trial); and vitamin A plus zinc (MD 3.10 kg, 95% CI 0.74 to 5.46; 80 participants, 1 trial). There was no evidence that any supplement affected the number of deaths or number of participants with sputum test positive results at the end of treatment. Authors' conclusions: There is limited evidence that high energy supplements and some combinations of zinc with other micronutrients may help people with tuberculosis to gain weight. There is not enough evidence to assess the effect of other combinations of nutrients. A number of relevant trials are in progress, and, where appropriate, the results will be incorporated into future updates of this review. Copyright © 2008 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
dc.subject alpha tocopherol
dc.subject arginine
dc.subject ascorbic acid
dc.subject cyanocobalamin
dc.subject folic acid
dc.subject iodine
dc.subject multivitamin
dc.subject nicotinic acid
dc.subject placebo
dc.subject pyridoxine
dc.subject retinol
dc.subject riboflavin
dc.subject selenium
dc.subject thiamine
dc.subject trace element
dc.subject tuberculostatic agent
dc.subject vitamin D
dc.subject zinc
dc.subject body weight
dc.subject caloric intake
dc.subject cholesterol diet
dc.subject clinical trial
dc.subject Cochrane Library
dc.subject drug megadose
dc.subject EMBASE
dc.subject follow up
dc.subject human
dc.subject Human immunodeficiency virus infection
dc.subject macronutrient
dc.subject malnutrition
dc.subject MEDLINE
dc.subject nutritional deficiency
dc.subject nutritional support
dc.subject review
dc.subject single drug dose
dc.subject sputum examination
dc.subject systematic review
dc.subject tuberculosis
dc.subject underweight
dc.subject vitamin supplementation
dc.title Nutritional supplements for people being treated for active tuberculosis
dc.type Review
dc.description.version Review
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