Cyclic AMP increase the Na+ permeability of the avian erythrocyte membrane by a process which does not involve protein phosphorylation

Date
1978
Authors
Weller M.
Laing W.
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Preparations of avian erythrocyte plasma membranes have been made which are in the form of sealed vesicles. Using these preparations the permeability of the membranes to Na+, K+, Mg2+ and Ca2+ was measured. Monobutyryl cyclic AMP and cyclic AMP increased the permeability to Na+ and Ca+ under conditions where no protein phosphorylation could occur. The only effect of phosphorylation of membrane proteins was to reduce Ca+ permeability. It is thus concluded that cyclic AMP increases Na+ permeability in the avian erythrocyte by a direct effect which does not involve protein phosphorylation.
Description
Keywords
calcium, cyclic amp, magnesium, potassium, protein kinase, sodium, animal experiment, blood and hemopoietic system, chicken, erythrocyte membrane, Animal, Calcium, Cell Membrane Permeability, Chickens, Cyclic AMP, Erythrocyte Membrane, Erythrocytes, Magnesium, Membrane Proteins, Potassium, Sodium
Citation
Molecular and Cellular Biochemistry
20
2