The time course of the phosphorylation of proteins in the synaptic plasma membrane and the effect of certain cations

Weller M. (1979)

Article

The phosphorylation of proteins in the synaptic plasma membrane is a rather slow reaction taking several minutes to saturate all the phosphate acceptor sites. (The time for half the protein bound phosphate groups to turnover is about 1 min). A divalent cation is needed as a cofactor for the reaction. At high (0.5 mm) ATP concentrations Mg2+ is more effective than Mn2+ but at low (10 μm) ATP concentrations the reverse is the case. Zn2+ and Ca2+ support very little phosphorylation. © 1979 Dr. W. Junk b.v. Publishers.

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