The significance of biochemical and structural changes in the development of the myocardiopathy of the Syrian hamster

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dc.contributor.author Lochner, A.
dc.contributor.author Brink, A. J.
dc.contributor.author Van Der Walt, J. J.
dc.date.accessioned 2011-05-15T15:59:46Z
dc.date.available 2011-05-15T15:59:46Z
dc.date.issued 1970
dc.identifier.citation Journal of Molecular and Cellular Cardiology
dc.identifier.citation 1
dc.identifier.citation 1
dc.identifier.issn 222828
dc.identifier.uri http://hdl.handle.net/10019.1/11353
dc.description.abstract In order to determine the causal factors in the development of the cardiomyopathy of the Syrian hamster, observations were made of myocardial histology, oxidative phosphorylation, high energy phosphate content, metabolism and mechanical activity of five age groups, ranging from 5 weeks to 10 months. Histological changes as well as biochemical abnormalities were present in the hearts of hamsters 5 weeks of age. With exception of a prolonged t-PH (time to peak height of contraction) period of the myopathic hearts of group I, tension development and contractility were normal up to 3 months of age. However, there was other evidence of disturbed function at 5 weeks of age, as shown by the length-tension curves. The significance and interrelationship of these findings are discussed. © 1970.
dc.subject glucose
dc.subject phosphate
dc.subject age
dc.subject animal
dc.subject animal disease
dc.subject article
dc.subject biomechanics
dc.subject disease model
dc.subject electron microscopy
dc.subject female
dc.subject hamster
dc.subject heart
dc.subject heart muscle
dc.subject inbreeding
dc.subject male
dc.subject metabolism
dc.subject muscle mitochondrion
dc.subject myocardial disease
dc.subject oxygen consumption
dc.subject pathology
dc.subject pathophysiology
dc.subject rodent disease
dc.subject species difference
dc.subject Age Factors
dc.subject Animal
dc.subject Biomechanics
dc.subject Disease Models, Animal
dc.subject Female
dc.subject Glucose
dc.subject Hamsters
dc.subject Heart
dc.subject Inbreeding
dc.subject Male
dc.subject Microscopy, Electron
dc.subject Mitochondria, Muscle
dc.subject Myocardial Diseases
dc.subject Myocardium
dc.subject Oxygen Consumption
dc.subject Phosphates
dc.subject Rodent Diseases
dc.subject Species Specificity
dc.title The significance of biochemical and structural changes in the development of the myocardiopathy of the Syrian hamster
dc.type Article
dc.description.version Article


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