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The significance of biochemical and structural changes in the development of the myocardiopathy of the Syrian hamster

dc.contributor.authorLochner, A.
dc.contributor.authorBrink, A. J.
dc.contributor.authorVan Der Walt, J. J.
dc.date.accessioned2011-05-15T15:59:46Z
dc.date.available2011-05-15T15:59:46Z
dc.date.issued1970
dc.identifier.citationJournal of Molecular and Cellular Cardiology
dc.identifier.citation1
dc.identifier.citation1
dc.identifier.issn222828
dc.identifier.urihttp://hdl.handle.net/10019.1/11353
dc.description.abstractIn order to determine the causal factors in the development of the cardiomyopathy of the Syrian hamster, observations were made of myocardial histology, oxidative phosphorylation, high energy phosphate content, metabolism and mechanical activity of five age groups, ranging from 5 weeks to 10 months. Histological changes as well as biochemical abnormalities were present in the hearts of hamsters 5 weeks of age. With exception of a prolonged t-PH (time to peak height of contraction) period of the myopathic hearts of group I, tension development and contractility were normal up to 3 months of age. However, there was other evidence of disturbed function at 5 weeks of age, as shown by the length-tension curves. The significance and interrelationship of these findings are discussed. © 1970.
dc.subjectglucose
dc.subjectphosphate
dc.subjectage
dc.subjectanimal
dc.subjectanimal disease
dc.subjectarticle
dc.subjectbiomechanics
dc.subjectdisease model
dc.subjectelectron microscopy
dc.subjectfemale
dc.subjecthamster
dc.subjectheart
dc.subjectheart muscle
dc.subjectinbreeding
dc.subjectmale
dc.subjectmetabolism
dc.subjectmuscle mitochondrion
dc.subjectmyocardial disease
dc.subjectoxygen consumption
dc.subjectpathology
dc.subjectpathophysiology
dc.subjectrodent disease
dc.subjectspecies difference
dc.subjectAge Factors
dc.subjectAnimal
dc.subjectBiomechanics
dc.subjectDisease Models, Animal
dc.subjectFemale
dc.subjectGlucose
dc.subjectHamsters
dc.subjectHeart
dc.subjectInbreeding
dc.subjectMale
dc.subjectMicroscopy, Electron
dc.subjectMitochondria, Muscle
dc.subjectMyocardial Diseases
dc.subjectMyocardium
dc.subjectOxygen Consumption
dc.subjectPhosphates
dc.subjectRodent Diseases
dc.subjectSpecies Specificity
dc.titleThe significance of biochemical and structural changes in the development of the myocardiopathy of the Syrian hamster
dc.typeArticle
dc.description.versionArticle


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