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Effect of a high fat diet on the metabolism and mechanical behaviour of the isolated rat heart

dc.contributor.authorReid J.V.O.
dc.contributor.authorLochner A.
dc.contributor.authorBrink A.J.
dc.date.accessioned2011-05-15T15:59:46Z
dc.date.available2011-05-15T15:59:46Z
dc.date.issued1970
dc.identifier.citationJournal of Molecular and Cellular Cardiology
dc.identifier.citation1
dc.identifier.citation3
dc.identifier.issn222828
dc.identifier.urihttp://hdl.handle.net/10019.1/11352
dc.description.abstractThe effects of a high fat, atherogenic diet was studied on the metabolism and mechanical behaviour of the isolated perfused rat heart. Palmitate and pyruvate metabolism were similar in control and fat-fed perfused hearts. Glucose uptake was lower in the fat-fed perfused heart, but the percentages of glucose converted to 14CO2 and glycogen were similar for the two groups. Explanations for the differences in glucose uptake are discussed. Fat-fed perfused hearts, with glucose as substrate, had significantly lower values for spontaneous rate, stress relaxation and tension time per minute than control hearts. With palmitate as substrate, the fat-fed perfused hearts had decreased coronary flow rates and a greater rate of tension increase on contraction. Contraction characteristics were different when hearts were perfused with glucose, compared with palmitate, in both dietary groups. © 1970.
dc.subjectcarbon
dc.subjectcarbon dioxide
dc.subjectglucose
dc.subjectglycogen
dc.subjectlactic acid derivative
dc.subjectlipid
dc.subjectpalmitic acid derivative
dc.subjectpyruvic acid derivative
dc.subjectanimal
dc.subjectarticle
dc.subjectatherogenic diet
dc.subjectbiomechanics
dc.subjectblood
dc.subjectcoronary artery blood flow
dc.subjectcoronary artery disease
dc.subjectfat intake
dc.subjectheart
dc.subjectheart muscle
dc.subjectmale
dc.subjectmetabolism
dc.subjectpathology
dc.subjectperfusion
dc.subjectphysiology
dc.subjectrat
dc.subjecttissue culture
dc.subjectAnimal
dc.subjectBiomechanics
dc.subjectCarbon Dioxide
dc.subjectCarbon Isotopes
dc.subjectCoronary Circulation
dc.subjectCoronary Disease
dc.subjectDiet, Atherogenic
dc.subjectDietary Fats
dc.subjectGlucose
dc.subjectGlycogen
dc.subjectHeart
dc.subjectLactates
dc.subjectLipids
dc.subjectMale
dc.subjectMyocardium
dc.subjectPalmitic Acids
dc.subjectPerfusion
dc.subjectPyruvates
dc.subjectRats
dc.subjectTissue Culture
dc.titleEffect of a high fat diet on the metabolism and mechanical behaviour of the isolated rat heart
dc.typeArticle
dc.description.versionArticle


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