Mitochondrial oxidative phosphorylation in myocardial ischaemia: effects of glycerol, glucose and insulin on anoxic hearts perfused at low pressure

Lochner A. ; Kotze J.C.N. ; Gevers W. (1976)


To determine whether metabolic intervention could prevent the depression in mitochondrial oxidative phosphorylation resulting from ischaemic perfusion of the isolated rat heart, hearts were perfused with glucose alone, glucose plus insulin, glycerol alone and a combination of glycerol, glucose and insulin. Addition of glucose, as well as glucose plus insulin to perfusates of ischaemic hearts improved mitochondrial oxidative phosphorylation. Perfusions of ischaemic hearts with glycerol, glucose and insulin were most effective: all parameters of mitochondrial function studied were significantly increased.

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