Two new polymorphic markers in the human proα2(1) collagen gene

Date
1985
Authors
Brebner D.K.
Grobler-Rabie A.F.
Bester A.J.
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Abstract
Structural defects in the human type 1 collagen genes are known to be the cause of several inherited disorders of connective tissue, such as osteogenesis imperfecta. The analysis and prenatal diagnosis of these disorders would be facilitated by establishing a set of polymorphic markers at these gene loci. We have previously reported the presence of an Msp 1 restriction fragment length polymorphism in the proα2(1) collagen genes of several South African populations (Grobler-Rabie et al., in press). This report describes the detection of a Bgl II and an EcoRI polymorphism in the proα2 gene of South African Blacks.
Description
Keywords
collagen type 1, collagen gene, dna polymorphism, dna probe, genetic engineering, genetic marker, heredity, human, human cell, normal human, normal value, priority journal, procollagen type 1 alpha2, restriction fragment length polymorphism, Chromosome Mapping, Collagen, Collagen Diseases, DNA Restriction Enzymes, Female, Genes, Genetic Markers, Human, Male, Negroid Race, Pedigree, Polymorphism (Genetics), Procollagen, South Africa, Support, Non-U.S. Gov't
Citation
Human Genetics
70
1