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Probiotic effect and dietary correlations on faecal microbiota profiles in irritable bowel syndrome

dc.contributor.authorStevenson, Cherylen_ZA
dc.contributor.authorBlaauw, Reneeen_ZA
dc.contributor.authorFredericks, Ernsten_ZA
dc.contributor.authorVisser, Janickeen_ZA
dc.contributor.authorRoux, Saartjieen_ZA
dc.date.accessioned2020-09-04T10:05:42Z
dc.date.available2020-09-04T10:05:42Z
dc.date.issued2019
dc.identifier.citationStevenson, C. 2019. Probiotic effect and dietary correlations on faecal microbiota profiles in irritable bowel syndrome. South African Journal of Clinical Nutrition, 2019:1-6, doi:10.1080/16070658.2019.1697038
dc.identifier.issn2221-1268 (online)
dc.identifier.issn1607-0658 (print)
dc.identifier.otherdoi:10.1080/16070658.2019.1697038
dc.identifier.urihttp://hdl.handle.net/10019.1/108795
dc.descriptionCITATION: Stevenson, C. 2019. Probiotic effect and dietary correlations on faecal microbiota profiles in irritable bowel syndrome. South African Journal of Clinical Nutrition, 2019:1-6, doi:10.1080/16070658.2019.1697038.
dc.descriptionThe original publication is available at https://www.tandfonline.com
dc.descriptionPublication of this article was funded by the Stellenbosch University Open Access Fund
dc.description.abstractObjective: Probiotics and nutrient intakes modulate gastrointestinal (GIT) microbiota and symptoms of irritable bowel syndrome (IBS). The extent to which these factors influence the microbiota is relatively unknown. The primary objective of this paper was to investigate the effect of a probiotic on gut microbiota and IBS symptoms. The secondary objective was exploring correlations between dietary intake and gut microbiota. Design: This study was an extension of a randomised clinical trial (Clinical Trials Registry NCT018867810). Dietary intake was recorded by three-day estimated food records. Faecal samples were collected at three time points: (1) baseline (A), (2) after eight weeks’ probiotic supplementation (Lactobacillus plantarum 299v) (B) and (3) following a two-week washout period (C). Total Bacteroides spp., Bifidobacteria bifidum and Lactobacillus plantarum were quantified by quantitative real-time polymerase chain reaction (qPCR). Results: Twenty-eight diarrhoea-predominant IBS (D-IBS) and 24 constipation-predominant IBS (C-IBS) patients participated. Lactobacillus plantarum profiles at baseline (A) were significantly different between C-IBS and D-IBS (−0.956 ± 1.239 vs. −1.700 ± 1.239; p = 0.024). There was no significant change in bacterial counts after completion of the trial (B) and following the washout period (C) between groups. In both groups there were significant direct correlations between fibre and Lactobacillus plantarum and inverse correlations between fibre and Bacteroides spp. There was no difference in symptom severity scores between treatment and placebo groups during the study. Conclusion: The probiotic had no effect on symptoms and GIT microbiota. Certain nutrients strongly correlate to certain bacterial profiles, suggesting that nutrients can significantly influence gastrointestinal microbiota composition.en_ZA
dc.description.urihttps://medpharm.tandfonline.com/doi/full/10.1080/16070658.2019.1697038
dc.format.extent7 pages
dc.language.isoen_ZAen_ZA
dc.publisherMedpharm Publications
dc.subjectIrritable colon -- Nutritionen_ZA
dc.subjectIrritable colon -- Treatmenten_ZA
dc.subjectProbioticsen_ZA
dc.titleProbiotic effect and dietary correlations on faecal microbiota profiles in irritable bowel syndromeen_ZA
dc.typeArticleen_ZA
dc.description.versionPublishers version
dc.rights.holderAuthors retain copyright


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