Browsing Research Articles (Clinical Pharmacology) by Title
Now showing items 47-66 of 70
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The pharmacokinetic behaviour of hypoxoside taken orally by patients with lung cancer in a phase I trial
(Health & Medical Publishing Group, 1995)Objective. To study the pharmacokinetic behaviour of hypoxoside taken orally by 24 patients with lung cancer. Design. Randomised open study with three single doses of 1 600, 2 400 and 3 200 mg standardised Hypoxis plant ... -
A population pharmacokinetic model is beneficial in quantifying hair concentrations of ritonavir-boosted atazanavir : a study of HIV-infected Zimbabwean adolescents
(BMC, 2020-08-03)Background: Adolescents experience higher levels of non-adherence to HIV treatment. Drug concentration in hair promises to be reliable for assessing exposure to antiretroviral (ARV) drugs. Pharmacokinetic modelling can ... -
The potential of Hypoxis hemerocallidea for herb-drug interaction
(Informa Healthcare, 2013)Context: Aqueous decoction of Hypoxis hemerocallidea Fisch. & C.A. Mey. (Hypoxidaceae) (Hypoxis) is widely consumed in Southern Africa by people living with HIV/AIDS, some of whom are on ARV and other medications. Objective: ... -
Renal safety of lithium in HIV-infected patients established on tenofovir disoproxil fumarate containing antiretroviral therapy : analysis from a randomized placebo-controlled trial
(BioMed Central, 2017-02-04)Background: The prevalence of bipolar disorder in HIV-infected patients is higher than the general population. Lithium is the most effective mood stabiliser, while tenofovir disoproxil fumarate (TDF) is frequently used ... -
Retinopathy of prematurity screening criteria and workload implications at Tygerberg Children’s Hospital, South Africa : a cross-sectional study
(Health & Medical Publishing Group, 2016-05-12)Background. Screening guidelines for retinopathy of prematurity (ROP) used in high-income countries are not appropriate for middle- income countries, and screening requirements may vary even between units within one ... -
Scombroid poisoning : case series of 10 incidents involving 22 patients
(Health & Medical Publishing Group, 1992)Scombroid poisoning is a form of ichthyosarcotoxism caused by the consumption of 'spoiled' fish of the dark meat varieties. It can be considered a mild-to-moderate form of 'food poisoning' and it occurs world-wide. Ten ... -
Scorpion sting in Southern Africa : diagnosis and management
(Health and Medical Publishing Group (HMPG), 2012-10)Most southern African scorpions are relatively harmless to humans, and although they can inflict quite a painful sting, no other toxic effects are expected to develop. However, a small number of scorpion species ... -
Scorpionism in South Africa : a report of 42 serious scorpion envenomations
(Health & Medical Publishing Group, 1993)Forty-two cases of serious scorpion envenomation, of which 4 had a fatal outcome, are presented. The clinical profile, differential diagnosis and management of scorpionism are discussed. Most envenomations occurred in the ... -
Screening strategies for adults with type 2 diabetes mellitus : a systematic review protocol
(BMC (part of Springer Nature), 2020-07-13)Background: There is limited evidence on whether screening for type 2 diabetes mellitus affects health outcomes. A recent systematic review of randomised clinical trials found only one trial that met their inclusion ... -
Shifting tasks from pharmacy to nonpharmacy personnel for providing antiretroviral therapy to people living with HIV : a systematic review and metaanalysis
(BMJ Publishing Group, 2017-8)Objectives Lay people or non-pharmacy health workers with training could dispense antiretroviral therapy (ART) in resource-constrained countries, freeing up time for pharmacists to focus on more technical tasks. ... -
Simulating therapeutic drug monitoring results for dose individualisation to maintain investigator blinding in a randomised controlled trial
(BioMed Central, 2017-06-07)Background: Therapeutic drug monitoring (TDM) is essential practice when dosing drugs with a narrow therapeutic index in order to achieve a plasma drug concentration within a narrow target range above the efficacy concentration ... -
Smoking, oncogenes and human lung cancer. A review of recent laboratory evidence linking smoking and lung cancer
(Health & Medical Publishing Group, 1988)Recent molecular genetic experiments conducted in the USA and The Netherlands have isolated specific mutations in human lung cancer cells. These data implicate the activation of the K-ras oncogene in the pathogenesis of ... -
Snake bite in southern Africa : diagnosis and management
(Health and Medical Publications Group (HMPG), 2012-10)Venomous snakes in southern Africa can, in broad terms, be divided into 3 groups: cytotoxic, neurotoxic and those that can induce haemostatic toxic effects. However, significant overlap of these effects may occur. Some ... -
Snake bites, spider bites and scorpion stings
(Health and Medical Publications Group (HMPG), 2012-10)Exposure of humans to natural toxins occurs via snake bites, spider bites and scorpion stings, or by plant or mushroom poisonings. According to the WHO (http://www.who.int/neglected_diseases/ diseases/snakebites/en/), ... -
Sodium valproate poisoning. A case report
(Health & Medical Publishing Group, 1985)A case of a severe overdose of sodium valproate (more than 10 times the therapeutic requirement) is discussed. The patient presented with central nervous, respiratory and cardiovascular depression and was treated with ... -
Spider bite in southern Africa : diagnosis and management
(Health and Medical Publications Group (HMPG), 2012-10)The medically important spiders of southern Africa can be divided into neurotoxic and cytotoxic groups. The neurotoxic spiders belong to the genus Latrodectus (button or widow spiders) and the cytotoxic spiders are ... -
Surfactant treatment before first breath for respiratory distress syndrome in preterm lambs : comparison of a peptide-containing synthetic lung surfactant with porcine-derived surfactant
(Dovepress, 2013-08)Background: In a recent study utilizing a saline-lavaged adult rabbit model, we described a significant improvement in systemic oxygenation and pulmonary shunt after the instillation of a novel synthetic peptide-containing ... -
Therapeutic drug monitoring of amlodipine and the Z-FHL/HHL ratio : Adherence tools in patients referred for apparent treatment-resistant hypertension
(Health & Medical Publishing Group, 2017)Background. Non-adherence to antihypertensives is a cause of ‘pseudo-treatment-resistant’ hypertension. Objective. To determine whether monitoring plasma amlodipine concentrations and inhibition of angiotensin-converting ... -
Toxicological screening for drugs of abuse in samples adulterated with household chemicals
(Health & Medical Publishing Group, 2002)Objectives. Urine samples that tested positive for two drugs of abuse, namely cannabis and methaqualone, were reassayed in the presence or absence of common household chemicals: Jik (sodium hypochlorite), Dettol (chloroxylenol), ... -
Treatment of a common ocular complaint
(Health & Medical Publishing Group, 1979)[No abstract available]
