Browsing Research Articles (Clinical Pharmacology) by Title
Now showing items 28-47 of 68
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Health-related quality of life and its association with medication adherence in active pulmonary tuberculosis– a systematic review of global literature with focus on South Africa
(BioMed Central, 2016-03-11)Introduction: Tuberculosis (TB) is a leading cause of morbidity and mortality in South Africa. Clinical parameters are important objective outcomes in TB; however they often are not directly correlated with subjective ... -
Health-related quality of life in South African patients with pulmonary tuberculosis
(Public Library of Science, 2017)Background: The evaluation of patient-reported health-related quality of life (HRQOL) in pulmonary tuberculosis (TB) contributes to a comprehensive understanding of the burden associated with this disease. The aim of ... -
How good are our guidelines? Four years of experience with the SAMJ’s AGREE II review of submitted clinical practice guideline
(Health & Medical Publishing Group, 2018)The South African Medical Journal (SAMJ) is an established source of clinical practice guidelines (CPGs) serving the local healthcare community. CPGs link professional societies and clinicians by guiding best practice ... -
How to evaluate health-related quality of life and its association with medication adherence in pulmonary tuberculosis – designing a prospective observational study in South Africa
(Frontiers Media, 2016)Introduction: Health-related quality of life (HRQOL) has become an important measure to identify and shape effective and patient-relevant healthcare interventions innovations through outcomes. Adherence to tuberculosis ... -
In vitro assessment of the interaction potential of ocimum basilicum (L.) extracts on CYP2B6, 3A4, and rifampicin metabolism
(Frontiers Media, 2020-04-30)ENGLISH ABSTRACT: Ocimum basilicum L. or basilicum is a common culinary herb, used as a traditional medicine for various medical conditions including HIV/AIDS and tuberculosis, in Africa. The objective of this study was ... -
The influence of non-steroidal anti-inflammatory and antithyroid agents on myeloperoxidase-catalysed activities of human leucocytes
(Health & Medical Publishing Group, 1979)Viable leucocytes obtained fresh from normal human subjects were shown to be able to catalyse the in vitro iodination of bovine serum albumin (BSA) in a H20 2-generating system. The rate and degree of iodination were greatly ... -
Inhibition of CYP2B6 by medicinal plant extracts : implication for use of efavirenz and nevirapine-based highly active anti-retroviral therapy (HAART) in resource-limited settings
(MDPI, 2016-02-16)Highly active antiretroviral therapy (HAART) has greatly improved health parameters of HIV infected individuals. However, there are several challenges associated with the chronic nature of HAART administration. For populations ... -
Inhibitory effects of non-steroidal anti-inflammatory drugs on human myeloperoxidase
(Health & Medical Publishing Group, 1979)Myeloperoxidase with an A420!280 ratio of 0,48 was prepared from normal human leucocytes. This partially purified preparation catalysed guaiacol oxidation, iodination of bovine serum albumin and de-iodination of ... -
Inhibitory interactions of Aspalathus linearis (Rooibos) extracts and compounds, aspalathin and Z-2-(β-D-glucopyranosyloxy)-3-phenylpropenoic acid, on cytochromes metabolizing hypoglycemic and hypolipidemic drugs
(MDPI, 2016-11-12)Rooibos extract, due to its glucose and lipid lowering effects, has potential as a nutraceutical for improvement of metabolic dysfunction. Potential herb-drug interactions as a result of the use of natural products are of ... -
Isgemiese hartsiekte as risiko vir algemene narkose en chirurgie
(Health & Medical Publishing Group, 1984)The risk of myocardial reinfarction in the patient who has suffered a pre-operative infarction is well documented. In a literature search, the cardiovascular risk implied by either asymptomatic or symptomatic ischaemic ... -
Moderate to severe HIV-associated neurocognitive impairment : a randomized placebo-controlled trial of lithium
(Wolters Kluwer Health, 2016-11)Background: HIV-associated neurocognitive disorder (HAND) remains highly prevalent despite effective anti-retroviral therapy (ART). A number of adjunctive pharmacotherapies for HAND have been studied with disappointing ... -
Morphological characterisation of the cell-growth inhibitory activity of rooperol and pharmacokinetic aspects of hypoxoside as an oral prodrug for cancer therapy
(Health & Medical Publishing Group, 1995)Hypoxoside is the major diglucoside isolated from the corms of the plant family Hypoxidaceae, It contains an. unusual E-pent-l-en-4-yne 5-carbon bridging unit with two distal catechol groups to which the glucose moieties ... -
Oligomeric substances in ampicillin preparations : a comparison of Penbritin, Famicillin and Petercillin
(Health & Medical Publishing Group, 1988)An investigation into the presence of potentially harmful oligomers in formulations of ampicillin for parenteral administration available in the RSA was undertaken by means of high-pressure liquid chromatography. Significant ... -
Origin of the enigmatic, circular, barren patches ('Fairy Rings') of the pro-Namib
(Academy of Science of South Africa, 2001)We have studied the enigmatic, circular, barren patches on the edge of the pro-Namib Desert in Namibia. An aerial photograph of the Wolwedans area (25°4.5′S, 15°59.5′E) showed that the patches had an average diameter of ... -
An overview of the biological disease modifying drugs available for arthritic conditions in South Africa
(Taylor & Francis, 2016)ENGLISH ABSTRACT: The past decade has seen a major change in the treatment options and strategies for rheumatoid arthritis (RA) and the other immune-mediated arthritic diseases. The disease modifying antirheumatic drugs ... -
An overview of the evidence and mechanisms of herb-drug interactions
(Frontiers, 2012-04-30)Despite the lack of sufficient information on the safety of herbal products, their use as alternative and/or complementary medicine is globally popular. There is also an increasing interest in medicinal herbs as precursor ... -
Permeability of intestinal mucosa to crystalline and tabletted isoniazid (INH)
(Health & Medical Publishing Group, 2003)When administered orally, isoniazid (INH), which continues to form the basis of most first-line standard antituberculosis regimens, reaches peak plasma concentrations of 3 - 5 μg/ml within 1 - 2 hours after ingestion ... -
The pharmacokinetic behaviour of hypoxoside taken orally by patients with lung cancer in a phase I trial
(Health & Medical Publishing Group, 1995)Objective. To study the pharmacokinetic behaviour of hypoxoside taken orally by 24 patients with lung cancer. Design. Randomised open study with three single doses of 1 600, 2 400 and 3 200 mg standardised Hypoxis plant ... -
A population pharmacokinetic model is beneficial in quantifying hair concentrations of ritonavir-boosted atazanavir : a study of HIV-infected Zimbabwean adolescents
(BMC, 2020-08-03)Background: Adolescents experience higher levels of non-adherence to HIV treatment. Drug concentration in hair promises to be reliable for assessing exposure to antiretroviral (ARV) drugs. Pharmacokinetic modelling can ... -
The potential of Hypoxis hemerocallidea for herb-drug interaction
(Informa Healthcare, 2013)Context: Aqueous decoction of Hypoxis hemerocallidea Fisch. & C.A. Mey. (Hypoxidaceae) (Hypoxis) is widely consumed in Southern Africa by people living with HIV/AIDS, some of whom are on ARV and other medications. Objective: ...
