Browsing Research Articles (Clinical Pharmacology) by Title
Now showing items 23-42 of 68
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Early bactericidal activity of ethambutol, pyrazinamide and the fixed combination of isoniazid, rifampicin and pyrazinamide (Rifater) in patients with pulmonary tuberculosis
(Health & Medical Publishing Group, 1996)The early bactericidal activity (EBA) of ethambutol, pyrazinamide and the fixed combination of isoniazid, rifampicin and pyrazinamide (Rifater: Mer National) was evaluated in patients with pulmonary tuberculosis who were ... -
Education and training for medicines development, regulation, and clinical research in emerging countries
(Frontiers Media, 2015)The aim of this satellite workshop held at the 17th World Congress of Basic and Clinical Pharmacology (WCP2014) was to discuss the needs, optimal methods and practical approaches for extending education and teaching of ... -
The effect of certain N-tritylated phenylalanine conjugates of amino-adenosine-3',5'-cyclic monophosphate on moloney murine leukaemia virus reverse transcriptase activity
(Academy of Science of South Africa (ASSAf), 2010-07)Moloney murine leukaemia virus M-MuLV) is a member of the retrovirus family. Its cloned reverse transcriptase RT), similarly to HIV type 1 reverse transcriptase HIV-1 RT), exhibits DNA-polymerase and ribonuclease H RNase ... -
Endogenous immunoreactive digitalis-like substance in neonatal serum and placental extracts
(Health & Medical Publishing Group, 1984)Therapeutic levels of digoxin in the serum of untreated neonates delivered to mothers who had not received the drug prenatally were detected by radio-immunoassay. Digoxin levels in neonates should be interpreted with care ... -
Evaluation of drug interaction potential of Labisia pumila (Kacip Fatimah) and its constituents
(Frontiers, 2014-08-08)ENGLISH ABSTRACT: Labisia pumila (Kacip Fatimah) is a popular herb in Malaysia that has been traditionally used in a number of women’s health applications such as to improve libido, relieve postmenopausal symptoms, and to ... -
Health-related quality of life and its association with medication adherence in active pulmonary tuberculosis– a systematic review of global literature with focus on South Africa
(BioMed Central, 2016-03-11)Introduction: Tuberculosis (TB) is a leading cause of morbidity and mortality in South Africa. Clinical parameters are important objective outcomes in TB; however they often are not directly correlated with subjective ... -
Health-related quality of life in South African patients with pulmonary tuberculosis
(Public Library of Science, 2017)Background: The evaluation of patient-reported health-related quality of life (HRQOL) in pulmonary tuberculosis (TB) contributes to a comprehensive understanding of the burden associated with this disease. The aim of ... -
How good are our guidelines? Four years of experience with the SAMJ’s AGREE II review of submitted clinical practice guideline
(Health & Medical Publishing Group, 2018)The South African Medical Journal (SAMJ) is an established source of clinical practice guidelines (CPGs) serving the local healthcare community. CPGs link professional societies and clinicians by guiding best practice ... -
How to evaluate health-related quality of life and its association with medication adherence in pulmonary tuberculosis – designing a prospective observational study in South Africa
(Frontiers Media, 2016)Introduction: Health-related quality of life (HRQOL) has become an important measure to identify and shape effective and patient-relevant healthcare interventions innovations through outcomes. Adherence to tuberculosis ... -
In vitro assessment of the interaction potential of ocimum basilicum (L.) extracts on CYP2B6, 3A4, and rifampicin metabolism
(Frontiers Media, 2020-04-30)ENGLISH ABSTRACT: Ocimum basilicum L. or basilicum is a common culinary herb, used as a traditional medicine for various medical conditions including HIV/AIDS and tuberculosis, in Africa. The objective of this study was ... -
The influence of non-steroidal anti-inflammatory and antithyroid agents on myeloperoxidase-catalysed activities of human leucocytes
(Health & Medical Publishing Group, 1979)Viable leucocytes obtained fresh from normal human subjects were shown to be able to catalyse the in vitro iodination of bovine serum albumin (BSA) in a H20 2-generating system. The rate and degree of iodination were greatly ... -
Inhibition of CYP2B6 by medicinal plant extracts : implication for use of efavirenz and nevirapine-based highly active anti-retroviral therapy (HAART) in resource-limited settings
(MDPI, 2016-02-16)Highly active antiretroviral therapy (HAART) has greatly improved health parameters of HIV infected individuals. However, there are several challenges associated with the chronic nature of HAART administration. For populations ... -
Inhibitory effects of non-steroidal anti-inflammatory drugs on human myeloperoxidase
(Health & Medical Publishing Group, 1979)Myeloperoxidase with an A420!280 ratio of 0,48 was prepared from normal human leucocytes. This partially purified preparation catalysed guaiacol oxidation, iodination of bovine serum albumin and de-iodination of ... -
Inhibitory interactions of Aspalathus linearis (Rooibos) extracts and compounds, aspalathin and Z-2-(β-D-glucopyranosyloxy)-3-phenylpropenoic acid, on cytochromes metabolizing hypoglycemic and hypolipidemic drugs
(MDPI, 2016-11-12)Rooibos extract, due to its glucose and lipid lowering effects, has potential as a nutraceutical for improvement of metabolic dysfunction. Potential herb-drug interactions as a result of the use of natural products are of ... -
Isgemiese hartsiekte as risiko vir algemene narkose en chirurgie
(Health & Medical Publishing Group, 1984)The risk of myocardial reinfarction in the patient who has suffered a pre-operative infarction is well documented. In a literature search, the cardiovascular risk implied by either asymptomatic or symptomatic ischaemic ... -
Moderate to severe HIV-associated neurocognitive impairment : a randomized placebo-controlled trial of lithium
(Wolters Kluwer Health, 2016-11)Background: HIV-associated neurocognitive disorder (HAND) remains highly prevalent despite effective anti-retroviral therapy (ART). A number of adjunctive pharmacotherapies for HAND have been studied with disappointing ... -
Morphological characterisation of the cell-growth inhibitory activity of rooperol and pharmacokinetic aspects of hypoxoside as an oral prodrug for cancer therapy
(Health & Medical Publishing Group, 1995)Hypoxoside is the major diglucoside isolated from the corms of the plant family Hypoxidaceae, It contains an. unusual E-pent-l-en-4-yne 5-carbon bridging unit with two distal catechol groups to which the glucose moieties ... -
Oligomeric substances in ampicillin preparations : a comparison of Penbritin, Famicillin and Petercillin
(Health & Medical Publishing Group, 1988)An investigation into the presence of potentially harmful oligomers in formulations of ampicillin for parenteral administration available in the RSA was undertaken by means of high-pressure liquid chromatography. Significant ... -
Origin of the enigmatic, circular, barren patches ('Fairy Rings') of the pro-Namib
(Academy of Science of South Africa, 2001)We have studied the enigmatic, circular, barren patches on the edge of the pro-Namib Desert in Namibia. An aerial photograph of the Wolwedans area (25°4.5′S, 15°59.5′E) showed that the patches had an average diameter of ... -
An overview of the biological disease modifying drugs available for arthritic conditions in South Africa
(Taylor & Francis, 2016)ENGLISH ABSTRACT: The past decade has seen a major change in the treatment options and strategies for rheumatoid arthritis (RA) and the other immune-mediated arthritic diseases. The disease modifying antirheumatic drugs ...
