Hypernatraemia in South African hospitalized patients

dc.contributor.authorAbohajir, Alien_ZA
dc.contributor.authorRensburg, Megan A.en_ZA
dc.contributor.authorDavids, M. Razeenen_ZA
dc.identifier.citationAbohajir, A., Rensburg, M. A. & Davids, M. R. 2019. Hypernatraemia in South African hospitalized patients. African Journal of Nephrology, 22(1):12-16, doi:10.21804/22-1-3285
dc.identifier.issn2518-4601 (online)
dc.identifier.issn2306-8205 (print)
dc.descriptionCITATION: Abohajir, A., Rensburg, M. A. & Davids, M. R. 2019. Hypernatraemia in South African hospitalized patients. African Journal of Nephrology, 22(1):12-16, doi:10.21804/22-1-3285.
dc.descriptionThe original publication is available at
dc.description.abstractBackground: Hypernatraemia is a common electrolyte problem in hospitalized patients and is associated with a high mortality rate. We determined the incidence, causes, management, and outcomes of hypernatraemia in adult hospitalized patients at a large South African tertiary hospital. Methods: A retrospective study was conducted at Tygerberg Hospital in Cape Town, South Africa. Adult patients with hypernatraemia (at least one serum sodium concentration ≥150 mmol/L) during a 3-month period in 2014 were identified from our laboratory database for inclusion. Results: There were 204 patients with hypernatraemia, a prevalence of 1.5%. Of these patients, 101 (49.5%) were male, and the mean age was 53 years. There were 66 patients (32.4%) who had hypernatraemia on admission, and 138 who developed it during the course of their stay in hospital. The overall in-hospital mortality was 38.7%, with higher rates for older patients and those with more severe degrees of hypernatraemia. Contributory causes which were most commonly present included dehydration/hypovolaemia (45%), followed by sepsis (39%). Net sodium gain, rather than water deficit, was identified as the main mechanism in most of the patients who developed hypernatraemia in the intensive care units. We found little evidence of any diagnostic work-up and also found that the details of fluid therapy and intake–output charting were poorly documented. Conclusions: There is a very high mortality rate in our hospitalized patients with hypernatraemia. The diagnostic work-up and therapy were often inadequate or poorly documented. The management of this important condition needs to be improved with the aid of standardized protocols.en_ZA
dc.format.extent5 pagesen_ZA
dc.publisherAfrican Association of Nephrologyen_ZA
dc.subjectWater-electrolyte imbalancesen_ZA
dc.subjectSodium -- Metabolism -- Disordersen_ZA
dc.titleHypernatraemia in South African hospitalized patientsen_ZA
dc.description.versionPublisher's version
dc.description.versionPublisher's version
dc.rights.holderAuthors retain copyrighten_ZA

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