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Association between health-related quality of life and medication adherence in pulmonary tuberculosis in South Africa

dc.contributor.authorKastien-Hilka, Tanjaen_ZA
dc.contributor.authorRosenkranz, Bernden_ZA
dc.contributor.authorSchwenkglenks, Matthiasen_ZA
dc.contributor.authorBennett, Bryan M.en_ZA
dc.contributor.authorSinanovic, Edinaen_ZA
dc.date.accessioned2019-02-04T09:52:08Z
dc.date.available2019-02-04T09:52:08Z
dc.date.issued2017-12-18
dc.identifier.citationKastien-Hilka, T., et al. 2017. Association between health-related quality of life and medication adherence in pulmonary tuberculosis in South Africa. Frontiers in Pharmacology, 8:919, doi:10.3389/fphar.2017.00919
dc.identifier.issn1663-9812 (online)
dc.identifier.otherdoi:10.3389/fphar.2017.00919
dc.identifier.urihttp://hdl.handle.net/10019.1/105380
dc.descriptionCITATION: Kastien-Hilka, T., et al. 2017. Association between health-related quality of life and medication adherence in pulmonary tuberculosis in South Africa. Frontiers in Pharmacology, 8:919, doi:10.3389/fphar.2017.00919.
dc.descriptionThe original publication is available at https://www.frontiersin.org
dc.description.abstractBackground: Health-related quality of life (HRQOL) and adherence to treatment are two often inter-related concepts that have implications for patient management and care. Tuberculosis (TB) and its treatment present a major public health concern in South Africa. The study aimed to evaluate the association between HRQOL and adherence in TB patients in South Africa. Methods: Four self-reported HRQOL and one self-reported adherence measures were used in an observational longitudinal multicentre study during 6-month standard TB treatment. These included the generic Short-Form 12 items (SF-12) and European Quality of Life 5 dimensions 5 levels (EQ-5D-5L), the disease-specific St. George's Respiratory Questionnaire (SGRQ) and the condition-specific Hospital Anxiety and Depression Scale (HADS) for HRQOL. Adherence was measured by the Morisky Medication Adherence Scale 8 items (MMAS-8). The relationship between both concepts was examined in 131 patients using Spearman's rho correlations, and linear regression models. Results: HRQOL improved over 6-month TB treatment, whereas adherence mean scores stayed constant with participants attaining a medium average level. Around 76% of patients reported to be high adherers and 24% were reporting a medium or low adherence. Associations between HRQOL and adherence were mainly weak. High adherence at treatment start was positively related to improvements in anxiety and depression after 6-month treatment. The overall improvement in pain and discomfort, and psychosocial health aspects over treatment time was positively, but weakly associated with adherence at 6 months of treatment. Conclusion: A positive relationship exists between adherence and HRQOL in TB in a South African setting, but this relationship was very weak, most likely because HRQOL is affected by a number of different factors and not limited to effects of adherence. Therefore, management of TB patients should, besides adequate drug treatment, address the specific mental and psychosocial needs.en_ZA
dc.description.urihttps://www.frontiersin.org/articles/10.3389/fphar.2017.00919/full
dc.format.extent7 pagesen_ZA
dc.language.isoen_ZAen_ZA
dc.publisherFrontiers Mediaen_ZA
dc.subjectPulmonary tuberculosisen_ZA
dc.subjectTreatment complianceen_ZA
dc.subjectTuberculosis patients -- Quality of lifeen_ZA
dc.titleAssociation between health-related quality of life and medication adherence in pulmonary tuberculosis in South Africaen_ZA
dc.typeArticleen_ZA
dc.description.versionPublisher's version
dc.rights.holderAuthors retain copyrighten_ZA


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