Interaction of verapamil hydrochloride and atropine sulphate on histamine-induced bronchoconstriction
Date
1985
Authors
Krivoy N.
Brandt H.D.
Bunn A.E.
Journal Title
Journal ISSN
Volume Title
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Abstract
Submaximal histamie dose-response curves were obtained on 34 dogs divided into six groups. These groups were: A (n = 6) untreated; B (n = 6) after atropine (1 mg/kg); C (n = 5) after verapamil inhalation (10 mg total dose); D (n = 5) after verapamil inhalation (100 mg total dose); E and F (n = 6) as for C and D but pre-treated with atropine (1 mg/kg). Total lung resistance (Rl) was measured in each case at increasing delivered concentrations of inhaled histamine and expressed as a ratio of baseline valve. For each group a composite mean curve was obtained and the maximal recorded responses (mean maximal resistance ratios) for the various groups were compared. It appears that the combination of verapamil inhalation (low dose) and atropine reduced the anticholinergic effect of atropine causing marked bronchoconstriction. This unexpected result depends on the verapamil dose since it was not present at the higher dose (group F).
Description
Keywords
atropine, calcium channel blocking agent, histamine, verapamil, animal experiment, breathing mechanics, bronchospasm, bronchus hyperreactivity, dog, dose response, drug comparison, drug interaction, drug response, drug therapy, inhalational drug administration, lung resistance, nonhuman, priority journal, respiratory system, therapy, Airway Resistance, Animal, Atropine, Bronchial Diseases, Constriction, Pathologic, Dogs, Dose-Response Relationship, Drug, Drug Interactions, Female, Histamine, Male, Support, Non-U.S. Gov't, Verapamil
Citation
Respiration
47
3
47
3