ITEM VIEW

HBV and HIV viral load but not microbial translocation or immune activation are associated with liver fibrosis among patients in South Africa

dc.contributor.authorMaponga, Tongai Gibsonen_ZA
dc.contributor.authorAndersson, Monique I.en_ZA
dc.contributor.authorVan Rensburg, Christoffel J.en_ZA
dc.contributor.authorArends, Joop E.en_ZA
dc.contributor.authorTaljaard, Jantjieen_ZA
dc.contributor.authorPreiser, Wolfgangen_ZA
dc.contributor.authorGlashoff, Richard H.en_ZA
dc.date.accessioned2018-05-14T05:38:17Z
dc.date.available2018-05-14T05:38:17Z
dc.date.issued2018-05-08
dc.identifier.citationMaponga, T. G., et al. 2018. HBV and HIV viral load but not microbial translocation or immune activation are associated with liver fibrosis among patients in South Africa. BMC Infectious Diseases, 18:214, doi:10.1186/s12879-018-3115-8
dc.identifier.issn1471-2334 (online)
dc.identifier.otherdoi:10.1186/s12879-018-3115-8
dc.identifier.urihttp://hdl.handle.net/10019.1/103993
dc.descriptionCITATION: Maponga, T. G., et al. 2018. HBV and HIV viral load but not microbial translocation or immune activation are associated with liver fibrosis among patients in South Africa. BMC Infectious Diseases, 18:214, doi:10.1186/s12879-018-3115-8.
dc.descriptionThe original publication is available at https://bmcinfectdis.biomedcentral.com
dc.descriptionPublication of this article was funded by the Stellenbosch University Open Access Fund.
dc.description.abstractBackground: Co-infection with HIV negatively impacts the progression of chronic hepatitis B virus (HBV) infection, including causing rapid progression to liver fibrosis. Sub-Saharan Africa represents arguably the most important intersection of high endemicity of both chronic hepatitis B virus (HBV) infection and HIV infection. Methods: We recruited 46 HBV/HIV-co-infected; 47 HBV-monoinfected; 39 HIV-monoinfected; and 37 HBV/HIV-uninfected patients from Tygerberg Hospital, Cape Town, South Africa. All HIV-infected patients were on antiretroviral therapy for ≥3 months. Liver stiffness measurements were assessed using the Fibroscan (Fibroscan 402, Echosens). Cell-based immunomarkers were measured by flow cytometry. Soluble serum/plasma immunomarkers were measured by Luminex technology and enzyme immunoassays. HIV (COBAS/Ampliprep TaqMan HIV-1) and HBV viral loads (in-house assay) were also performed. Results: HBV/HIV co-infected patients showed significantly higher levels of immune activation %CD8+/HLA-DR+/CD38+ (median 30%, interquartile range: 17–53) and %CD8+/PD-1 (median 22%, interquartile range: 15–33), p ≤ 0.01 compared to all other study groups. Despite this, the HBV-mono-infected group had the highest proportion of patients with advanced liver fibrosis (≥13 kPa) as measured by Fibroscan (18%). HBV mono-infected patients showed highest expression of most cytokines including IL-17 and basic fibroblastic growth factor. There was significant positive correlation between detectable HIV and HBV viral replication and liver fibrosis but not immune activation or gut translocation. Discussion: Highly-active antiretroviral therapy, including tenofovir, is effective against both HIV and HBV. Earlier therapy in the co-infected patients may therefore have controlled viral replication leading to better fibrosis scores when compared to HBV mono-infection in this study. On-going HBV and HIV viraemia, rather than microbial translocation or immune activation, appear to be the drivers of liver fibrosis. Moderate to advanced liver fibrosis in HBV-mono-infection may well indicate poor access to screening and treatment of HBV infection.
dc.description.urihttps://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-018-3115-8
dc.language.isoen_ZAen_ZA
dc.publisherBioMed Central
dc.subjectHIV infectionsen_ZA
dc.subjectHepatitis Ben_ZA
dc.subjectCytokinesen_ZA
dc.subjectAntiretroviral agentsen_ZA
dc.subjectLiver -- Diseasesen_ZA
dc.titleHBV and HIV viral load but not microbial translocation or immune activation are associated with liver fibrosis among patients in South Africaen_ZA
dc.typeArticleen_ZA
dc.date.updated2018-05-13T03:33:17Z
dc.description.versionPublisher's version
dc.rights.holderAuthor retains copyright


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

ITEM VIEW