Chronic obstructive pulmonary disease (COPD) : neutrophils, macrophages and lymphocytes in patients with anterior tuberculosis compared to tobacco related COPD
Date
2018-03-27
Journal Title
Journal ISSN
Volume Title
Publisher
BioMed Central
Abstract
Objective: The inflammatory profile of chronic obstructive pulmonary disease (COPD) related to tobacco is known
in certain studies while that of the post tuberculosis form is not yet known. This study aimed to evaluate the levels
of neutrophils, macrophages and lymphocytes cells in sputum of COPD patients with history of smoking or anterior
tuberculosis. Enumeration of cells in samples was analyzed using standard microscopy.
Results: We enrolled 92 participants, 46 (50%) were COPD subjects comprising 22 (47.83%) smokers and 24 (52.17%)
with anterior tuberculosis while 46 (50%) healthy persons constituted the control group. The levels of neutrophils,
lymphocytes and monocytes were statistically higher in COPD patients compared to the control group with p-values
of 0.0001 respectively. Neutrophils levels were higher in COPD patients with history of tobacco than in COPD patients
with anterior tuberculosis with a mean rate of 4.72 × 106/ml and 2.48 × 106/ml respectively (p = 0.04). The monocytes
and lymphocytes levels were not statistically different between the two sub-groups of COPD patients with p-value
of 0.052 and 0.91 respectively. Neutrophils are the only inflammatory cells that were significantly higher in COPD
patients with history of smoking as compared to COPD patients with anterior tuberculosis.
Description
CITATION: Guiedem, E., et al. 2018. Chronic obstructive pulmonary disease (COPD): neutrophils, macrophages and lymphocytes in patients with anterior tuberculosis compared to tobacco related COPD. BMC Research Notes, 11:192, doi:10.1186/s13104-018-3309-6.
The original publication is available at https://bmcresnotes.biomedcentral.com
The original publication is available at https://bmcresnotes.biomedcentral.com
Keywords
Tuberculosis, Tobacco, Lungs -- Diseases, Obstructive
Citation
Guiedem, E., et al. 2018. Chronic obstructive pulmonary disease (COPD): neutrophils, macrophages and lymphocytes in patients with anterior tuberculosis compared to tobacco related COPD. BMC Research Notes, 11:192, doi:10.1186/s13104-018-3309-6