ITEM VIEW

Mucus and mucins: do they have a role in the inhibition of the human immunodeficiency virus?

dc.contributor.authorMall, Anwar Sulemanen_ZA
dc.contributor.authorHabte, Habtomen_ZA
dc.contributor.authorMthembu, Yolandaen_ZA
dc.contributor.authorPeacocke, Juliaen_ZA
dc.contributor.authorDe Beer, Corenaen_ZA
dc.date.accessioned2017-10-09T05:39:04Z
dc.date.available2017-10-09T05:39:04Z
dc.date.issued2017-10-06
dc.identifier.citationMall, A. S. et al. 2017. Mucus and mucins : do they have a role in the inhibition of the human immunodeficiency virus? Virology Journal, 14:192, doi:10.1186/s12985-017-0855-9.en_ZA
dc.identifier.issn1743-422X (online)
dc.identifier.otherdoi:10.1186/s12985-017-0855-9
dc.identifier.urihttp://hdl.handle.net/10019.1/102295
dc.descriptionCITATION: Mall, A. S. et al. 2017. Mucus and mucins : do they have a role in the inhibition of the human immunodeficiency virus? Virology Journal, 14:192, doi:10.1186/s12985-017-0855-9.en_ZA
dc.descriptionThe original publication is available at https://virologyj.biomedcentral.comen_ZA
dc.description.abstractBackground: Mucins are large O-linked glycosylated proteins which give mucus their gel-forming properties. There are indications that mucus and mucins in saliva, breast milk and in the cervical plug inhibit the human immunodeficiency virus (HIV-1) in an in vitro assay. Main body of abstract: Crude mucus gels form continuous layers on the epithelial surfaces of the major internal tracts of the body and protect these epithelial surfaces against aggressive luminal factors such as hydrochloric acid and pepsin proteolysis in the stomach lumen, the movement of hard faecal pellets in the colon at high pressure, the effects of shear against the vaginal epithelium during intercourse and the presence of foreign substances in the respiratory airways. Tumour-associated epitopes on mucins make them suitable as immune-targets on malignant epithelial cells, rendering mucins important as diagnostic and prognostic markers for various diseases, even influencing the design of mucin-based vaccines. Sub-Saharan Africa has the highest prevalence of HIV-AIDS in the world. The main points of viral transmission are via the vaginal epithelium during sexual intercourse and mother-to-child transmission during breast-feeding. There have been many studies showing that several body fluids have components that prevent the transmission of HIV-1 from infected to non-infected persons through various forms of contact. Crude saliva and its purified mucins, MUC5B and MUC7, and the purified mucins from breast milk, MUC1 and MUC4 and pregnancy plug cervical mucus (MUC2, MUC5AC, MUC5B and MUC6), inhibit HIV-1 in an in vitro assay. There are conflicting reports of whether crude breast-milk inhibits HIV-1 in an in vitro assay. However studies with a humanised BLT mouse show that breast-milk does inhibit HIV and that breast-feeding is still advisable even amongst HIV-positive women in under-resourced areas, preferably in conjunction with anti-retroviral treatment. Conclusion: These findings raise questions of how such a naturally occurring biological substance such as mucus, with remarkable protective properties of epithelial surfaces against aggressive luminal factors in delicate locations, could be used as a tool in the fight against HIV-AIDS, which has reached epidemic proportions in sub-Saharan Africa.en_ZA
dc.description.urihttps://virologyj.biomedcentral.com/articles/10.1186/s12985-017-0855-9en_ZA
dc.format.extent14 pagesen_ZA
dc.language.isoen
dc.publisherBioMed Centralen_ZA
dc.subjectMucusen_ZA
dc.subjectMucinsen_ZA
dc.subjectSalivaen_ZA
dc.subjectHIV (Viruses)en_ZA
dc.titleMucus and mucins: do they have a role in the inhibition of the human immunodeficiency virus?en_ZA
dc.typeArticleen_ZA
dc.date.updated2017-10-08T03:28:17Z
dc.description.versionPublisher's versionen_ZA
dc.rights.holderAuthors retain copyrighten_ZA


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

ITEM VIEW