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Ageing-Associated Oxidative Stress and Inflammation Are Alleviated by Products from Grapes

dc.contributor.authorPetersen, K. S.
dc.contributor.authorSmith, Carine
dc.date.accessioned2017-09-07T07:39:45Z
dc.date.available2017-09-07T07:39:45Z
dc.date.issued2016
dc.identifier.urihttp://hdl.handle.net/10019.1/102197
dc.description.abstractAdvanced age is associated with increased incidence of a variety of chronic disease states which share oxidative stress and inflammation as causative role players. Furthermore, data point to a role for both cumulative oxidative stress and low grade inflammation in the normal ageing process, independently of disease. Therefore, arguably the best route with which to address premature ageing, aswell as age-associated diseases such as diabetes, cardiovascular disease, and dementia, is preventative medicine aimed at modulation of these two responses, which are intricately interlinked. In this review, we provide a detailed account of the literature on the communication of these systems in the context of ageing, but with inclusion of relevant data obtained in other models. In doing so, we attempted to more clearly elucidate or identify the most probable cellular or molecular targets for preventative intervention. In addition, given the absence of a clear pharmaceutical solution in this context, together with the everincreasing consumer bias for natural medicine, we provide an overview of the literature on grape (Vitis vinifera) derived products, for which beneficial effects are consistently reported in the context of both oxidative stress and inflammation.en_ZA
dc.language.isoen_ZAen_ZA
dc.subjectAdvanced aging, premature ageing, natural medicine, grape products, oxidative stress, inflammationen_ZA
dc.titleAgeing-Associated Oxidative Stress and Inflammation Are Alleviated by Products from Grapesen_ZA
dc.typeArticleen_ZA


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