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Association between tuberculosis and a polymorphic NFκB binding site in the interferon γ gene

dc.contributor.authorRossouw M.
dc.contributor.authorNel H.J.
dc.contributor.authorCooke G.S.
dc.contributor.authorVan Helden P.D.
dc.contributor.authorHoal E.G.
dc.date.accessioned2011-05-15T15:57:03Z
dc.date.available2011-05-15T15:57:03Z
dc.date.issued2003
dc.identifier.citationLancet
dc.identifier.citation361
dc.identifier.citation9372
dc.identifier.issn1406736
dc.identifier.other10.1016/S0140-6736(03)13491-5
dc.identifier.urihttp://hdl.handle.net/10019.1/10188
dc.description.abstractInterferon γ is believed to be crucial for host defence against many infections. To test the hypothesis that a polymorphism in the gene for interferon γ (IFNG) is associated with susceptibility to tuberculosis, we did two independent investigations. In a case-control study of 313 tuberculosis cases, we noted a significant association between a polymorphism (+874A→T) in IFNG and tuberculosis in a South African population (p=0.0055). This finding was replicated in a family-based study, in which the transmission disequilibrium test was used in 131 families (p=0.005). The transcription factor NFκB binds preferentially to the +874T allele, which is over-represented in controls. This preferential binding suggests that genetically determined variability in interferon γ and expression might be important for the development of tuberculosis.
dc.subjectDNA
dc.subjectgamma interferon
dc.subjectimmunoglobulin enhancer binding protein
dc.subjecttranscription factor
dc.subjectallele
dc.subjectarticle
dc.subjectbinding affinity
dc.subjectbinding site
dc.subjectcase control study
dc.subjectcontrolled study
dc.subjectdisease course
dc.subjectDNA polymorphism
dc.subjectfamily study
dc.subjectgene expression
dc.subjectgenetic analysis
dc.subjectgenetic association
dc.subjectgenetic susceptibility
dc.subjectgenetic variability
dc.subjecthuman
dc.subjectinfection sensitivity
dc.subjectmajor clinical study
dc.subjectpopulation research
dc.subjectpriority journal
dc.subjectSouth Africa
dc.subjecttuberculosis
dc.subjectAlleles
dc.subjectCase-Control Studies
dc.subjectGenetic Predisposition to Disease
dc.subjectHumans
dc.subjectInterferon-alpha
dc.subjectNF-kappa B
dc.subjectPolymorphism, Single Nucleotide
dc.subjectSouth Africa
dc.subjectTuberculosis
dc.titleAssociation between tuberculosis and a polymorphic NFκB binding site in the interferon γ gene
dc.typeArticle
dc.description.versionArticle


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