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An evidence-based approach to recurrent pregnancy loss

dc.contributor.authorVan Niekerk, Elzaan C.en_ZA
dc.contributor.authorSiebert, Ignoen_ZA
dc.contributor.authorKruger, Theunis Fransen_ZA
dc.date.accessioned2017-05-02T06:33:31Z
dc.date.available2017-05-02T06:33:31Z
dc.date.issued2013-07-26
dc.identifier.citationVan Niekerk, E. C., Siebert, I. & Kruger, T. F. 2013. An evidence-based approach to recurrent pregnancy loss. South African Journal of Obstetrics and Gynaecology, 19(3):61-65, doi:10.7196/SAJOG.670.
dc.identifier.issn2305-8862 (online)
dc.identifier.issn0038-2329 (print)
dc.identifier.otherdoi:10.7196/SAJOG.670
dc.identifier.urihttp://hdl.handle.net/10019.1/101517
dc.descriptionCITATION: Van Niekerk, E. C., Siebert, I. & Kruger, T. F. 2013. An evidence-based approach to recurrent pregnancy loss. South African Journal of Obstetrics and Gynaecology, 19(3):61-65, doi:10.7196/SAJOG.670.
dc.descriptionThe original publication is available at http://www.sajog.org.za
dc.description.abstractRecurrent pregnancy loss (RPL) can be defined as more than two to three consecutive miscarriages before 24 weeks’ gestation. A literature review was done to provide an evidence-based approach to RPL, identifying the risk factors and causes and also looking at the various special investigations that form part of the work-up and trying to assess which have been proven to be effective or of negative impact, and which of the management options lead to a better outcome. We concluded that the following special investigations should be part of the work-up for all patients with RPL: (i) genetic counselling and karyotyping of the abortus; (ii) anticardiolipin antibodies and lupus anticoagulant testing must be done on two occasions, 6 - 8 weeks apart; (iii) all patients qualify for a pelvic ultrasound scan and hysteroscopy; (iv) syphilis testing must be done routinely; and (v) testing of thyroid function and glucose monitoring/glycosylated haemoglobin (HbA1c) measurement must be done in all patients with a history of thyroid disease or diabetes mellitus, or clinical manifestations thereof. In approximately 50% of couples the cause of RPL remains unexplained, even after evaluation.en_ZA
dc.description.urihttp://www.sajog.org.za/index.php/SAJOG/article/view/670
dc.format.extent5 pages
dc.language.isoen_ZAen_ZA
dc.publisherHealth & Medical Publishing Group
dc.subjectMiscarriageen_ZA
dc.subjectPregnancy -- Complicationsen_ZA
dc.titleAn evidence-based approach to recurrent pregnancy lossen_ZA
dc.typeArticleen_ZA
dc.description.versionPublisher's version
dc.rights.holderAuthors retain copyright


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