Sequence polymorphism in the rrs gene of Mycobacterium tuberculosis is deeply rooted within an evolutionary clade and is not associated with streptomycin resistance
Date
2001
Authors
Victor T.C.
Van Rie A.
Jordaan A.M.
Richardson M.
Van der Spuy G.D.
Beyers N.
Van Helden P.D.
Warren R.
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
A mutation (C-to-T transition) at position 491 of the rrs gene was identified in a Mycobacterium tuberculosis strain family (n = 208 isolates) that was predominant in a suburb of Cape Town, South Africa. This nucleotide change is not involved in streptomycin resistance, and we suggest caution in assuming that all mutations in genes targeted by antituberculosis drugs confer drug resistance.
Description
Keywords
cytosine, streptomycin, thymine, antibiotic resistance, article, bacterial gene, controlled study, evolution, gene targeting, mutation, Mycobacterium tuberculosis, nonhuman, nucleotide sequence, priority journal, sequence analysis, South Africa, strain difference, Antibiotics, Antitubercular, Bacterial Proteins, Drug Resistance, Bacterial, Evolution, Molecular, Genes, Bacterial, Humans, Mutation, Mycobacterium tuberculosis, Polymorphism, Genetic, Polymorphism, Restriction Fragment Length, Streptomycin, Tuberculosis, Pulmonary, Actinobacteria (class), Bacteria (microorganisms), Mycobacterium, Mycobacterium tuberculosis, uncultured actinomycete
Citation
Journal of Clinical Microbiology
39
11
39
11