Sequence polymorphism in the rrs gene of Mycobacterium tuberculosis is deeply rooted within an evolutionary clade and is not associated with streptomycin resistance

Victor T.C. ; Van Rie A. ; Jordaan A.M. ; Richardson M. ; Van der Spuy G.D. ; Beyers N. ; Van Helden P.D. ; Warren R. (2001)


A mutation (C-to-T transition) at position 491 of the rrs gene was identified in a Mycobacterium tuberculosis strain family (n = 208 isolates) that was predominant in a suburb of Cape Town, South Africa. This nucleotide change is not involved in streptomycin resistance, and we suggest caution in assuming that all mutations in genes targeted by antituberculosis drugs confer drug resistance.

Please refer to this item in SUNScholar by using the following persistent URL:
This item appears in the following collections: