IS6110-Mediated Deletion Polymorphism in Isogenic Strains of Mycobacterium tuberculosis

Sampson S.L. ; Richardson M. ; Van Helden P.D. ; Warren R.M. (2004)


Previous studies have described IS6110-mediated polymorphism as an important driving force in Mycobacterium tuberculosis genome evolution and have provided indirect evidence for IS6110-driven deletion events. This study provides the first description of an IS6110-mediated deletion event in truly isogenic strains. We also provide further support for the hypothesis that the region from Rv1754 to Rv1765 is a hot spot for IS6110 insertion and deletion events.

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