Stability of Polymorphic GC-Rich Repeat Sequence-Containing Regions of Mycobacterium tuberculosis

Richardson M. ; Van Der Spuy G.D. ; Sampson S.L. ; Beyers N. ; Van Helden P.D. ; Warren R.M. (2004)

Article

Mycobacterium tuberculosis cultures were subjected to DNA fingerprinting with IS6110- and polymorphic GC-rich sequence (PGRS)-containing probes. The PGRS banding patterns remained highly stable during multiple cultures of specimens from one disease episode (0.5% changed) and during transmission in patients with close contact (1.9% changed). Characteristic PGRS-restriction fragment length polymorphism motifs for different strain groupings may indicate distant evolutionary events leading to the differentiation of M. tuberculosis strain lineages.

Please refer to this item in SUNScholar by using the following persistent URL: http://hdl.handle.net/10019.1/10127
This item appears in the following collections: