Spread of a low-fitness drug-resistant Mycobacterium tuberculosis strain in a setting of high human immunodeficiency virus prevalence

Strauss O.J. ; Warren R.M. ; Jordaan A. ; Streicher E.M. ; Hanekom M. ; Falmer A.A. ; Albert H. ; Trollip A. ; Hoosain E. ; Van Helden P.D. ; Victor T.C. (2008)


The fitness cost associated with the evolution of resistance to rifampin in Mycobacterium tuberculosis may be different in clinical isolates compared to in vitro-generated mutants. An atypical Beijing strain (attenuated phenotype) demonstrated the ability to spread despite acquiring resistance to rifampin. Transmission was linked to human immunodeficiency virus coinfection (P = 0.029), raising concern for the spread of drug resistance in vulnerable populations. Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Please refer to this item in SUNScholar by using the following persistent URL: http://hdl.handle.net/10019.1/10108
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