Modulation of Hepatic Drug Metabolizing Enzymes and Oxidative Status by Rooibos (Aspalathus linearis) and Honeybush (Cyclopia intermedia), Green and Black (Camellia sinensis) Teas in Rats

Date
2003
Authors
Marnewick, J. L.
Joubert, E.
Swart, P.
Der Westhuizen, F. V.
Gelderblom, W. C.
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Rooibos and honeybush teas significantly (P < 0.05) enhanced the activity of cytosolic glutathione S-transferase alpha. A significant (P < 0.05) to marginal (P < 0.1) increase in the activity of the microsomal UDP-glucuronosyl transferase was obtained with unprocessed rooibos and honeybush teas, respectively. Oxidized glutathione (GSSG) levels were significantly (P < 0.05) reduced in the liver of all tea treated rats while reduced glutathione (GSH) was markedly increased in the liver of the herbal tea treated rats. These changes resulted in a significant (P < 0.05) increase in the GSH/GSSG ratio by the unprocessed, processed rooibos and unprocessed honeybush teas. Green and black teas markedly to significantly decreased the oxygen radical absorbance capacity in liver homogenates, respectively. Modulation of phase II drug metabolizing enzymes and oxidative status in the liver may be important events in the protection against adverse effects related to mutagenesis and oxidative damage.
Description
Keywords
drug metabolizing enzyme, glucuronosyltransferase, glutathione, glutathione disulfide, glutathione transferase, liver enzyme, oxygen radical, animal experiment, animal tissue, antioxidant activity, article, controlled study, drug metabolism, enzyme activity, enzyme assay, herbal medicine, honeybush, liver, liver cytosol, liver homogenate, liver metabolism, liver microsome, male, modulation, mutagenesis, nonhuman, oxidation, processing, rat, rooibos, statistical significance, tea, Animals, Aspalathus, Beverages, Camellia sinensis, Fabaceae, Flavonoids, Glucuronosyltransferase, Glutathione, Glutathione Transferase, Liver, Male, Oxidation-Reduction, Phenols, Rats, Rats, Inbred F344, Reactive Oxygen Species, Tea, Animalia, Aspalathus, Aspalathus linearis, Camellia, Camellia sinensis, Cyclopia
Citation
Journal of Agricultural and Food Chemistry
51
27