Centre for Evidence-Based Health Care
Recent Submissions
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Authorship, plagiarism and conflict of interest : views and practices from low/ middle-income country health researchers
(BMJ Publishing Group, 2017-11)Objectives To document low/middle-income country (LMIC) health researchers’ views about authorship, redundant publication, plagiarism and conflicts of interest and how common poor practice was in their institutions. Design ...
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Protocol for a qualitative synthesis of barriers and facilitators in implementing guidelines for diagnosis of tuberculosis
(BMJ Publishing Group, 2017-6)Introduction Despite the introduction of new tests and guidelines for diagnosis of tuberculosis (TB), worldwide case detection rate of TB is still suboptimal. This could be in part explained by the poor implementation ...
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Epidemiology of rubella infection in Cameroon : a 7-year experience of measles and rubella case-based surveillance, 2008–2014
(BMJ Publishing Group, 2017-4)Objective The aim of this study was to estimate the proportion of rubella disease in a measles case-based surveillance in Cameroon prior to rubella vaccine introduction into the national immunisation programme. Design ...
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Isoniazid for preventing tuberculosis in HIV-infected children
(John Wiley & Sons, Ltd. on behalf of The Cochrane Collaboration, 2017)Background: Tuberculosis (TB) is an important cause of illness and death in HIV‐positive children living in areas of high TB prevalence. We know that isoniazid prophylaxis prevents TB in HIV‐negative children following TB ...
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Interventions for treating tuberculous pericarditis
(John Wiley & Sons, Ltd. on behalf of The Cochrane Collaboration, 2017)Background: Tuberculous pericarditis – tuberculosis infection of the pericardial membrane (pericardium) covering the heart – is becoming more common. The infection can result in fluid around the heart or fibrosis of the ...
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Interventions for improving adults’ use of primary oral health care services
(John Wiley & Sons, Ltd. on behalf of The Cochrane Collaboration, 2017)This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To assess the effectiveness of interventions aimed at improving adults’ use of primary dental care services in order to improve their ...
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Implementation strategies for health systems in low-income countries : an overview of systematic reviews
(John Wiley & Sons, Ltd. on behalf of The Cochrane Collaboration, 2017)Background: A key function of health systems is implementing interventions to improve health, but coverage of essential health interventions remains low in low‐income countries. Implementing interventions can be challenging, ...
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Governance arrangements for health systems in low-income countries : an overview of systematic reviews
(John Wiley & Sons, Ltd. on behalf of The Cochrane Collaboration, 2017)Background: Governance arrangements include changes in rules or processes that determine authority and accountability for health policies, organisations, commercial products and health professionals, as well as the involvement ...
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Interleukin-2 as an adjunct to antiretroviral therapy for HIV-positive adults
(John Wiley & Sons, Ltd. on behalf of The Cochrane Collaboration, 2017)Background: Human immunodeficiency virus (HIV) continues to be a leading cause of morbidity and mortality, particularly in sub‐Saharan Africa. Although antiretroviral drugs have helped to improve the quality of life and ...
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Delivery arrangements for health systems in low-income countries : an overview of systematic reviews
(John Wiley & Sons, Ltd. on behalf of The Cochrane Collaboration, 2017)Background: Delivery arrangements include changes in who receives care and when, who provides care, the working conditions of those who provide care, coordination of care amongst different providers, where care is provided, ...
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Caregiver involvement in interventions for improving children’s dietary intake and physical activity behaviors
(John Wiley & Sons, Ltd. on behalf of The Cochrane Collaboration, 2017)This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To assess the effects of caregiver involvement in interventions for improving children's dietary intake and physical activity behavior, ...
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Financial arrangements for health systems in low-income countries : an overview of systematic reviews
(John Wiley & Sons, Ltd. on behalf of The Cochrane Collaboration, 2017)Background: One target of the Sustainable Development Goals is to achieve "universal health coverage, including financial risk protection, access to quality essential health‐care services and access to safe, effective, ...
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Beta‐blockers for hypertension
(John Wiley & Sons, Ltd. on behalf of The Cochrane Collaboration, 2017)Background: Beta-blockers refer to a mixed group of drugs with diverse pharmacodynamic and pharmacokinetic properties. They have shown longterm beneficial effects on mortality and cardiovascular disease (CVD) when used ...
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National stakeholders’ perceptions of the processes that inform the development of national clinical practice guidelines for primary healthcare in South Africa
(BioMed Central, 2018-07-31)Background: There is increased international focus on improving the rigour of clinical practice guideline (CPG) development practices. However, few empirical studies on CPG development have been conducted in low- ...
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Integration of care for hypertension and diabetes : a scoping review assessing the evidence from systematic reviews and evaluating reporting
(BioMed Central, 2018-06-20)Background: With the rise in premature mortality rate from non-communicable disease (NCD), there is a need for evidence-based interventions. We evaluated existing systematic reviews on effectiveness of integration of ...
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A description of pharmacological analgesia administration by public sector advanced life support paramedics in the City of Cape Town
(Elsevier, 2017-03)Introduction: Emergency Medical Services are ideally placed to provide relief of acute pain and discomfort. The objectives of this study were to describe pre-hospital pain management practices by Emergency Medical Services ...
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Quality of pilot trial abstracts in heart failure is suboptimal : a systematic survey
(BioMed Central, 2018-05-31)Background: Pilot trials are miniature researches carried out with the sole aim of acting as the precursor for larger more definitive studies. Abstracts are used to summarize and introduce the findings to the reading ...
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Nurse led home-based care for people with HIV/AIDS
(BioMed Central, 2018-03-27)Background: Home-based care is used in many countries to increase quality of life and limit hospital stay, particularly where public health services are overburdened. Home-based care objectives for HIV/AIDS can include medical ...
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South African primary health care allied health clinical practice guidelines : the big picture
(BioMed Central, 2018-01-29)Background: Good quality clinical practice guidelines (CPGs) are a vehicle to implementing evidence into allied health (AH) care. This paper reports on the current ‘state of play’ of CPGs in a lower-to-middle-income ...
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Evidence synthesis and translation for nutrition interventions to combat micronutrient deficiencies with particular focus on food fortification
(MDPI, 2016)Over two billion people suffer from micronutrient deficiencies. Food fortification is a prominent nutrition intervention to combat such deficiencies; however, its effectiveness, risks, and ethical implications vary depending ...
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Effectiveness of resistance strength training in children and adolescents with ≥30% total body surface area : a systematic review
(AOSIS Publishing, 2016)Purpose: Children and adolescents with burn injuries are at risk of living with social, educational, physical and psychological impairments. The systematic review aimed to ascertain the effectiveness of resistance strength ...
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Risk of cardiovascular disease among teachers in Cape Town : findings of the South African PaCT pilot study
(Health & Medical Publishing Group, 2016)Background. The accelerating epidemic of cardiovascular disease (CVD) and other non-communicable diseases (NCDs) highlights the need to establish long-term cohort studies in Africa. Objective. The Partnership for Cohort ...
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High prevalence of cardiovascular risk factors in Durban South African Indians : the Phoenix Lifestyle Project
(Health & Medical Publishing Group, 2016)Background. Previous studies show a high prevalence of cardiovascular (CV) risk factors in South African (SA) Asian Indians, with the emergence of premature coronary artery disease in young Indian subjects. Objective. ...
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Inappropriate antibiotic prescribing : a cross-sectional study in Swaziland
(Medpharm Publications, 2016)Background: A cross-sectional study was performed to determine the one-month prevalence of inappropriate antibiotic prescribing at the outpatient department of Hlatikulu Government Hospital, Swaziland. A survey was also ...
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Burden of diabetes and first evidence for the utility of HbA1c for diagnosis and detection of diabetes in urban Black South Africans : the Durban diabetes study
(Public Library of Science, 2016)Objective: Glycated haemoglobin (HbA1c) is recommended as an additional tool to glucose-based measures (fasting plasma glucose [FPG] and 2-hour plasma glucose [2PG] during oral glucose tolerance test [OGTT]) for the diagnosis ...
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Acceptability and feasibility of mHealth and community-based directly observed antiretroviral therapy to prevent mother-to-child HIV transmission in South African pregnant women under Option B+ : an exploratory study
(Dove Medical Press, 2016)ENGLISH SUMMARY : Objective: To examine the acceptability and feasibility of mobile health (mHealth)/short message service (SMS) and community-based directly observed antiretroviral therapy (cDOT) as interventions to improve ...
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Advocating for efforts to protect African children, families, and communities from the threat of infectious diseases : report of the First International African Vaccinology Conference
(African Field Epidemiology Network, 2016)One means of improving healthcare workers' knowledg e of and attitudes to vaccines is through running v accine conferences which are accessible, affordable, and relevant to their everyday work. Va rious vaccinology ...
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Primary care clinical practice guidelines in South Africa : qualitative study exploring perspectives of national stakeholders
(Biomed CentralPublisher's version, 2017-08)Background Clinical practice guidelines (CPGs) are common tools in policy and clinical practice informing clinical decisions at the bedside, governance of health facilities, health insurer and government spending, and ...
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Urban and rural prevalence of diabetes and pre- diabetes and risk factors associated with diabetes in Tanzania and Uganda
(Taylor & Francis Open, 2016)ENGLISH SUMMARY : Background: The increase in prevalence of diabetes and pre-diabetes in sub-Saharan Africa underlines the importance of understanding its magnitude and causes in different population ...
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Current knowledge and future research directions on fecal bacterial patterns and their association with asthma
(Frontiers Media, 2016)ENGLISH SUMMARY : Asthma is a complex respiratory condition that involves interplay between genetic predisposition, environmental, and immunological factors (Edwards et al., 2012). It is considered to be one of the most ...
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