Centre for Evidence-Based Health Care
Recent Submissions
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Quality of pilot trial abstracts in heart failure is suboptimal : a systematic survey
(BioMed Central, 2018-05-31)Background: Pilot trials are miniature researches carried out with the sole aim of acting as the precursor for larger more definitive studies. Abstracts are used to summarize and introduce the findings to the reading ...
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South African primary health care allied health clinical practice guidelines : the big picture
(BioMed Central, 2018-01-29)Background: Good quality clinical practice guidelines (CPGs) are a vehicle to implementing evidence into allied health (AH) care. This paper reports on the current ‘state of play’ of CPGs in a lower-to-middle-income ...
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Risk of cardiovascular disease among teachers in Cape Town : findings of the South African PaCT pilot study
(Health & Medical Publishing Group, 2016)Background. The accelerating epidemic of cardiovascular disease (CVD) and other non-communicable diseases (NCDs) highlights the need to establish long-term cohort studies in Africa. Objective. The Partnership for Cohort ...
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Burden of diabetes and first evidence for the utility of HbA1c for diagnosis and detection of diabetes in urban Black South Africans : the Durban diabetes study
(Public Library of Science, 2016)Objective: Glycated haemoglobin (HbA1c) is recommended as an additional tool to glucose-based measures (fasting plasma glucose [FPG] and 2-hour plasma glucose [2PG] during oral glucose tolerance test [OGTT]) for the diagnosis ...
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Acceptability and feasibility of mHealth and community-based directly observed antiretroviral therapy to prevent mother-to-child HIV transmission in South African pregnant women under Option B+ : an exploratory study
(Dove Medical Press, 2016)ENGLISH SUMMARY : Objective: To examine the acceptability and feasibility of mobile health (mHealth)/short message service (SMS) and community-based directly observed antiretroviral therapy (cDOT) as interventions to improve ...
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Advocating for efforts to protect African children, families, and communities from the threat of infectious diseases : report of the First International African Vaccinology Conference
(African Field Epidemiology Network, 2016)One means of improving healthcare workers' knowledg e of and attitudes to vaccines is through running v accine conferences which are accessible, affordable, and relevant to their everyday work. Va rious vaccinology ...
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Primary care clinical practice guidelines in South Africa : qualitative study exploring perspectives of national stakeholders
(Biomed CentralPublisher's version, 2017-08)Background Clinical practice guidelines (CPGs) are common tools in policy and clinical practice informing clinical decisions at the bedside, governance of health facilities, health insurer and government spending, and ...
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Urban and rural prevalence of diabetes and pre- diabetes and risk factors associated with diabetes in Tanzania and Uganda
(Taylor & Francis Open, 2016)ENGLISH SUMMARY : Background: The increase in prevalence of diabetes and pre-diabetes in sub-Saharan Africa underlines the importance of understanding its magnitude and causes in different population ...
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Current knowledge and future research directions on fecal bacterial patterns and their association with asthma
(Frontiers Media, 2016)ENGLISH SUMMARY : Asthma is a complex respiratory condition that involves interplay between genetic predisposition, environmental, and immunological factors (Edwards et al., 2012). It is considered to be one of the most ...
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An approach for setting evidence-based and stakeholder-informed research priorities in low- and middle-income countries
(World Health Organization, 2016)ENGLISH SUMMARY : To derive evidence-based and stakeholder-informed research priorities for implementation in African settings, the international research consortium Collaboration for Evidence-Based Healthcare and Public ...
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The efficacy and safety of complete pericardial drainage by means of intrapericardial fibrinolysis for the prevention of complications of pericardial effusion : a systematic review protocol
(BMJ Publishing Group, 2016)ENGLISH SUMMARY : Introduction: Intrapericardial fibrinolysis has been proposed as a means of preventing complications of pericardial effusion such as cardiac tamponade, persistent and recurrent pericardial effusion, ...
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Epidemiology, health systems and stakeholders in rheumatic heart disease in Africa : a systematic review protocol
(BMJ Publishing Group, 2016)ntroduction: Rheumatic heart disease (RHD) is a chronic disease affecting the heart valves, secondary to group A streptococcal infection (GAS) and subsequent acute rheumatic fever (ARF). However, RHD cure and preventative ...
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The effects of shifting tasks from pharmacy to non-pharmacy personnel for providing antiretroviral therapy to people living with HIV : a systematic review protocol
(BMJ Publishing Group, 2016)ENGLISH SUMMARY : Introduction: Shifting selected antiretroviral therapy (ART) tasks from specialised healthcare workers to those with shorter or less formal training has been implemented in resource-limited settings ...
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Achieving universal testing for malaria
(BMJ Publishing Group, 2016)ENGLISH SUMMARY : Rapid diagnostic tests have the potential to reduce the overtreatment of malaria by 95%, but time and extensive logistical, behavioural, and technical interventions may be required to achieve this.
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Hepatitis B infection awareness, vaccine perceptions and uptake, and serological profile of a group of health care workers in Yaounde, Cameroon
(BioMed Central, 2016)ENGLISH SUMMARY : Background: Cameroon is one of the countries in Africa with the highest burden of Hepatitis B infection. Health care workers are known to be at risk of occupational exposure to blood and other infectious ...
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Assessing variability in results in systematic reviews of diagnostic studies
(BioMed Central, 2016)ENGLISH SUMMARY : Background: To describe approaches used in systematic reviews of diagnostic test accuracy studies for assessing variability in estimates of accuracy between studies and to provide guidance in this ...
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Interactive weekly mobile phone text messaging plus motivational interviewing in promotion of breastfeeding among women living with HIV in South Africa : study protocol for a randomized controlled trial
(BioMed Central, 2017-07-17)Background: South Africa recently phased out access to free formula milk in the public sector in support of breastfeeding for women living with HIV. Few women living with HIV in South Africa choose breastfeeding and among ...
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Changes in lipid profiles of HIV+ adults over nine months at a Harare HIV clinic : a longitudinal study
(Hindawi Publishing Corporation, 2016)ENGLISH SUMMARY : HIV infection, together with ART, is associated with changes in biochemical, metabolic parameters and lipid profiles. The aim of this study was to compare changes in lipid profiles among HIV positive ...
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Evaluating evidence-based health care teaching and learning in the undergraduate human nutrition; occupational therapy; physiotherapy; and speech, language and hearing therapy programs at a sub-Saharan African academic institution
(Public Library of Science, 2017-02-16)Background: It is important that all undergraduate healthcare students are equipped with evidence-based health care (EBHC) knowledge and skills to encourage evidence-informed decision-making after graduation. We assessed ...
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Building capacity in clinical epidemiology in Africa : experiences from Masters programmes
(BioMed Central, 2017-02-27)ENGLISH SUMMARY : Background: To describe and contrast programmatic offering of Clinical Epidemiology Masters programmes in Africa, to evaluate experiences of graduates and faculty, and assess if graduates are playing ...
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Correlation of rpoB mutations with minimal inhibitory concentration of rifampin and rifabutin in Mycobacterium tuberculosis in an HIV/AIDS endemic setting, South Africa
(Frontiers, 2016-12-05)ENGLISH SUMMARY : Treatment of tuberculosis (TB) and HIV co-infections is often complicated by drug-to-drug interactions between anti-mycobacterial and anti-retroviral agents. Rifabutin (RFB) is an alternative to rifampin ...
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The epidemiology of tuberculosis in health care workers in South Africa : a systematic review
(BioMed Central, 2016-08-20)ENGLISH SUMMARY : Background: In South Africa, workplace acquired tuberculosis (TB) is a significant occupational problem among health care workers. In order to manage the problem effectively it is important to know the ...
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South African clinical practice guidelines quality measured with complex and rapid appraisal instruments
(BioMed Central, 2016-04-27)ENGLISH SUMMARY : Background: Critically appraising the quality of clinical practice guidelines (CPGs) is an essential element of evidence implementation. Critical appraisal considers the quality of CPG construction and ...
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To adopt, to adapt, or to contextualise? The big question in clinical practice guideline development
(BioMed Central, 2016-09-13)ENGLISH SUMMARY : Aim: Developing new clinical practice guidelines (CPGs) can be time-consuming and expensive. A more efficient approach could be to adopt, adapt or contextualise recommendations from existing good quality ...
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Research evidence and policy : qualitative study in selected provinces in South Africa and Cameroon
(BioMed Central, 2015-09-03)ENGLISH SUMMARY : Background: The translation of research into policy and practice is enhanced by policymakers who can recognise and articulate their information needs and researchers that understand the policymakers’ ...
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Mapping South African allied health primary care clinical guideline activity : establishing a stakeholder reference sample
(BioMed Central, 2016-10-10)ENGLISH SUMMARY : Background: Little is known about allied health (AH) clinical practice guideline (CPG) activity in South Africa, and particularly in relation to primary health care (PHC). This paper reports on a scoping ...
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Developing the African national health research systems barometer
(BioMed Central, 2016-07-22)ENGLISH SUMMARY : Background: A functional national health research system (NHRS) is crucial in strengthening a country’s health system to promote, restore and maintain the health status of its population. Progress towards ...
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Enhancing evidence informed policymaking in complex health systems : lessons from multi-site collaborative approaches
(BioMed Central, 2016-03-17)ENGLISH SUMMARY : Background: There is an increasing interest worldwide to ensure evidence-informed health policymaking as a means to improve health systems performance. There is a need to engage policymakers in collaborative ...
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Urban–rural and geographic differences in overweight and obesity in four sub-Saharan African adult populations : a multi-country cross-sectional study
(BioMed Central, 2016-10-28)ENGLISH SUMMARY : Background: Overweight and obesity are on the rise in developing countries including sub-Saharan Africa. We undertook a four-country survey to show the collective burden of these health conditions as they ...
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Factors that affect the uptake of community-based health insurance in low-income and middle-income countries : a systematic protocol
(BMJ Publishing Group, 2014)ENGLISH SUMMARY : Introduction: Many people residing in low-income and middle-income countries (LMICs) are regularly exposed to catastrophic healthcare expenditure. It is therefore pertinent that LMICs should finance their ...
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