The effect of methylprednisolone, given prior to cardiopulmonary bypass, on indices of gas exchange
Date
1996
Authors
Coetzer M.
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Abstract
This study examined the effect of a single dose of methyl-prednisolone ((MP) 30 mg/kg) given before cardiopulnionary bypass (CPB) on the alveolar/arterial oxygen gradient (AaDO2) and arterial oxygen tension/inspired oxygen fraction quotient (PaO2/FiO2) at 1, 24 and 48 hours after CPB. The study was prospective and patients were randomly allocated to one of two groups. Of the 295 patients entered into the study, 165 received MP and 130 did not. The mortality rate in the MP group was 4.24% and in the control group the mortality rate was 3.85% (P = 0.894). No difference in the postoperative PaO2/FiO2 and AaDO2 could be demonstrated when patients who had received MP were compared with those who had not received MP pre-operatively.
Description
Keywords
methylprednisolone, adult, aged, arterial oxygen tension, article, blood gas analysis, cardiopulmonary bypass, cardiovascular function, clinical trial, complement activation, controlled clinical trial, controlled study, drug effect, female, gas exchange, heart output, human, intravenous drug administration, lung alveolus oxygen tension, lung function, major clinical study, male, randomized controlled trial
Citation
Cardiovascular Journal of South Africa
SUPPL. 4
SUPPL. 4