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Now showing items 31-40 of 97

The 5-year outcome of multidrug resistant tuberculosis patients in the Cape Province of South Africa

Schaaf H.S.; Botha P.; Beyers N.; Gie R.P.; Vermeulen H.A.S.; Groenewald P.; Coetzee G.J.; Donald P.R. (1996)

Little is known about the outcome of multidrug resistant (MDR) tuberculosis (TB) in developing countries. In this study, 443 patients with MDR-TB, defined as resistance to two Or more antituberculosis drugs, were identified ...

Prospective evaluation of World Health Organization criteria to assist diagnosis of tuberculosis in children

Houwert K.A.F.; Borggreven P.A.; Schaaf H.S.; Nel E.; Donald P.R.; Stolk J. (1998)

Because of the difficulty in confirming childhood tuberculosis (TB), the World Health Organization (WHO) proposes a hierarchical approach to diagnosis using history and certain clinical features to help to improve the ...

HIV and childhood tuberculosis: The way forward

Cotton M.F.; Schaaf H.S.; Hesseling A.C.; Madhi S.A. (2004)

Tuberculosis has been a major cause of morbidity and mortality in under-resourced communities. By causing progressive immunodeficiency, the human immunodeficiency virus (HIV) increases susceptibility to tuberculosis in an ...

The burden of childhood tuberculosis: A public health perspective

Marais B.J.; Obihara C.C.; Warren R.M.; Schaaf H.S.; Gie R.P.; Donald P.R. (2005)

The burden of childhood tuberculosis (TB) reflects recent transmission within a community and the level of TB control achieved within the adult (maintenance host) population. Children contribute little to the maintenance ...

A prospective evaluation of children under the age of 5 years living in the same household as adults with recently diagnosed pulmonary tuberculosis

Beyers N.; Gie R.P.; Schaaf H.S.; Van Zyl S.; Talent J.M.; Nel E.D.; Donald P.R. (1997)

SETTING: A South African suburb with a high tuberculosis incidence (>800/100 000). OBJECTIVE: To determine the prevalence of tuberculosis infection and disease in children less than 5 years of age who were in close household ...

Pharmacokinetics of isoniazid, rifampin,and pyrazinamide in children younger than two years of age with tuberculosis: Evidence for implementation of revised World Health Organization recommendations

Thee S.; Seddon J.A.; Donald P.R.; Seifart H.I.; Werely C.J.; Hesseling A.C.; Rosenkranz B.; Roll S.; Magdorf K.; Schaaf H.S. (2011)

Beijing and Haarlem genotypes are overrepresented among children with drug-resistant tuberculosis in the Western Cape province of South Africa

Marais B.J.; Victor T.C.; Hesseling A.C.; Barnard M.; Jordaan A.; Brittle W.; Reuter H.; Beyers N.; Van Helden P.D.; Warren R.M.; Schaaf H.S. (2006)

Drug resistance among children with culture-confirmed tuberculosis (TB) provides an accurate measure of transmitted drug resistance within the community. We describe the genotype diversity in children with culture-confirmed ...

Mycobacterium tuberculosis transmission is not related to household genotype in a setting of high endemicity

Marais B.J.; Hesseling A.C.; Schaaf H.S.; Gie R.P.; Van Helden P.D.; Warren R.M. (2009)

Among the different strains of Mycobacterium tuberculosis, Beijing has been identified as an emerging genotype. Enhanced transmissibility provides a potential mechanism for genotype selection. This study evaluated whether ...

Pediatric meningitis in the Western Cape Province of South Africa

Donald P.R.; Cotton M.F.; Hendricks M.K.; Schaaf H.S.; De Villiers J.N.; Willemse T.E. (1996)

During the 9 years 1985-1993 a prospective survey of all cases of meningitis in children < 13 years of age presenting to our hospital in the Western Cape Province of South Africa was carried out. Two-thousand-nine-hundre ...

Genome and MIC stability in Mycobacterium tuberculosis and indications for continuation of use of isoniazid in multidrug-resistant tuberculosis

Victor T.C.; Warren R.; Butt J.L.; Jordaan A.M.; Felix J.V.; Venter A.; Sirgel F.A.; Schaaf H.S.; Donald P.R.; Richardson M.; Cynamon M.H.; Van Helden P.D. (1997)

Mycobacterium tuberculosis strains resistant to two or more of the first line antituberculosis drugs (MDR) are a serious threat to successful tuberculosis control programmes. For this retrospective study, 85 follow-up drug ...

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