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Now showing items 21-30 of 474
The occurance of genetic variations in the MYH9 gene and their association with CKD in a mixed South African population
(Stellenbosch : Stellenbosch University, 2012-12)
ENGLISH ABSTRACT: The purpose of this study was to investigate the association of the selected MYH9 single nucleotide polymorphisms (SNPs) with chronic kidney disease (CKD) and its related co-morbidities in the South African ...
Investigation of the relationship between genetic and environmental risk factors associated with obesity and insulin resistance in South African patients with non-alcoholic fatty liver disease(NAFLD)
(Stellenbosch : Stellenbosch University, 2012-12)
ENGLISH ABSTRACT: Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease in the world. The disease spectrum of NAFLD extends from steatosis (types 1,2) to non-alcoholic steatohepatitis (NASH) ...
Mycobacterium tuberculosis : genetic and phenotypic comparison
(Stellenbosch : Stellenbosch University, 2002-03)
ENGLISH ABSTRACT: This study exploits the Mycobacterium tuberculosis H37Rv genome sequence data in
the context of M. tuberculosis clinical isolates, to elucidate genetic variation, and examine the
phenotypic and molecular ...
Molecular identification and characterisation of rodent- and shrew-borne Hantaviruses
(Stellenbosch : University of Stellenbosch, 2010-12)
ENGLISH ABSTRACT: Throughout history disease entities have been described which match the
description of diseases now known to be caused by hantaviruses; however these
viruses were first identified as the aetiologic agent ...
The effect of 5'-aminoimidazole-4-carboxamide ribonucleoside (AICAR) and 5'-aminoimidazole-4-carboxamide-ribonucleoside-phosphate (ZMP) on myocardial glucose uptake
(Stellenbosch : Stellenbosch University, 2005-03)
ENGLISH ABSTRACT: Introduction: Exercise increases skeletal muscle glucose uptake via AMP-activated
protein kinase (AMPK) activation and GLUT4 translocation from cytosol to cell
membrane. It also promotes glucose ...
A pathologic role for angiotensin II and endothelin-1 in cardiac remodelling and ischaemia and reperfusion injury in a rat model of the metabolic syndrome
(Stellenbosch : University of Stellenbosch, 2006-03)
Introduction: Obesity, which is implicated in the development of the metabolic
syndrome (MS) is reaching epidemic proportions worldwide. MS significantly
increases the risk of developing cardiovascular disease, which ...
The effect of creatine supplementation on myocardial metabolism and function in sedentary and exercised rats
(Stellenbosch : University of Stellenbosch, 2010-12)
ENGLISH ABSTRACT: Background: There has been a dramatic increase in the use of dietary creatine
supplementation among sports men and women, and by clinicians as a therapeutic
agent in muscular and neurological diseases. ...
Identification of candidate genes and testing for association with tuberculosis in humans
(Stellenbosch : Stellenbosch University, 2007-12)
ENGLISH ABSTRACT: This research investigated human candidate genes for susceptibility to tuberculosis and the effect
of various factors on time to sputum conversion in the admixed South African Coloured (SAC)
population. ...
Development of a pathology-supported genetic test for improved clinical management of patients diagnosed with multiple sclerosis
(Stellenbosch : University of Stellenbosch, 2010-12)
ENGLISH ABSTRACT: The aetiology of multiple sclerosis (MS) remains largely unknown, due to its multifactorial nature with environmental and genetic factors contributing to the risk. Several investigations highlighted the ...
Treatment of first episode schizophrenia with low-dose haloperidol : a study in the Western Cape Province of South Africa
(Stellenbosch : Stellenbosch University, 2003--03)
ENGLISH ABSTRACT: Although schizophrenia is traditionally viewed as an illness with a very poor
prognosis, research over the last few years indicates that early intervention may
substantially improve the long-term outcome ...