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The Magpie Trial: A randomised trial comparing magnesium sulphate with placebo for pre-eclampsia. Outcome for children at 18 months
(2007)
Objective: To assess the long-term effects of in utero exposure to magnesium sulphate for children whose mothers had pre-eclampsia. Design: Assessment at 18 months of age for children whose mothers were recruited to the ...
Pharmacodynamic equivalence of a decapeptyl 3-month SR formulation with the 28-day SR formulation in patients with advanced prostate cancer
(2004)
Aims: The objective of the study was to assess the pharmacodynamic equivalence of LHRH analogue triptorelin 3-month and 28-day SR formulations. Methods: Patients with documented locally advanced or metastatic prostate ...
Patient-controlled epidural analgesia versus continuous infusion for labour analgesia: A meta-analysis
(2002)
Background. Patient-controlled epidural analgesia (PCEA) is a relatively new method of maintaining labour analgesia. There have been many studies performed that have compared the efficacy of PCEA with continuous epidural ...
Effect of tramadol on depth of anaesthesia
(1996)
We have studied 51 patients who were anaesthetized with propofol and suxamethonium followed by 0.7% isoflurane and 66% nitrous oxide in oxygen to see if tramadol caused lightening of anaesthesia. A two-channel EEG was ...
Efficacy and tolerability of pantoprazole 40 mg versus 80 mg in patients with reflux oesophagitis
(1996)
Background: Pantoprazole is a substituted benzimidazole which is a potent inhibitor of gastric acid secretion by its action upon H+,K+-ATPase. Methods: Pantoprazole 40 mg and 80 mg were compared in a randomized double-blind ...
Comparable clinical efficacy and tolerability of 20 mg pantoprazole and 20 mg omeprazole in patients with grade I reflux oesophagitis
(2001)
Background: Several clinical trials have shown that pantoprazole (40 mg) and omeprazole (40 or 20 mg) have similar efficacy and safety in the treatment of grade II-IV reflux oesophagitis (Savary-Miller classification). ...
Esomeprazole 40 mg administered intravenously has similar safety and efficacy profiles to the oral formulation in patients with erosive esophagitis
(2004)
Background/Aims: An intravenous formulation of esomeprazole has been developed for use in patients where oral administration is not appropriate. This study evaluated safety after 1 and 4 weeks, and efficacy after 4 weeks' ...
Clinical trial: Intravenous pantoprazole vs. ranitidine for the prevention of peptic ulcer rebleeding: A multicentre, multinational, randomized trial
(2009)
Background: Controlled pantoprazole data in peptic ulcer bleeding are few. Aim: To compare intravenous (IV) pantoprazole with IV ranitidine for bleeding ulcers. Methods: After endoscopic haemostasis, 1256 patients were ...
No clinical benefit of adding cisapride to pantoprazole for treatment of gastro-oesophageal reflux disease
(2001)
Objective Although a proton pump inhibitor (PPI) and a prokinetic drug are often combined for the medical treatment of gastro-oesophageal reflux disease (GORD), there are few well-conducted clinical studies on the efficacy ...
Effects of folic acid and zinc sulfate on male factor subfertility: A double-blind, randomized, placebo-controlled trial
(2002)
Objective: To study the effects of folic acid and zinc sulfate treatment on semen variables in fertile and subfertile men. Design: Double-blind, placebo-controlled interventional study. Setting: Two outpatient fertility ...