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Value of different staging systems for predicting neurological outcome in childhood tuberculous meningitis

Van Toorn R.; Springer P.; Laubscher J.A.; Schoeman J.F. (2012)

BACKGROUND: The stage of tuberculous meningitis (TBM) at presentation is strongly associated with prognosis. OBJECTIVE: To compare different staging systems for TBM in predicting outcome. METHODS: The associations of ...

Rapid on-site evaluation of transbronchial aspirates: Randomised comparison of two methods

Diacon A.H.; Koegelenberg C.F.N.; Schubert P.; Brundyn K.; Louw M.; Wright C.A.; Bolliger C.T. (2010)

The value of different staining methods for rapid analysis of transbronchial needle aspirates during bronchoscopy has not been explored. In the present study, we compared a Papanicolaou-based rapid stain, prepared by a ...

Opportunities for chemoprophylaxis in children with culture-confirmed tuberculosis

Du Preez K.; Hesseling A.C.; Mandalakas A.M.; Marais B.J.; Schaaf H.S. (2011)

Maternal HIV infection and antibody responses against vaccine-preventable diseases in uninfected infants

Jones C.E.; Naidoo S.; De Beer C.; Esser M.; Kampmann B.; Hesseling A.C. (2011)

Context: Altered immune responses might contribute to the high morbidity and mortality observed in human immunodeficiency virus (HIV)-exposed uninfected infants. Objective: To study the association of maternal HIV infection ...

Early mortality and loss to follow-up in HIV-infected children starting antiretroviral therapy in Southern Africa

Fenner L.; Brinkhof M.W.G.; Keiser O.; Weigel R.; Cornell M.; Moultrie H.; Prozesky H.; Technau K.; Eley B.; Vaz P.; Pascoe M.; Giddy J.; Van Cutsem G.; Wood R.; Egger M.; Davies M.-A. (2010)

Background: Many HIV-infected children in Southern Africa have been started on antiretroviral therapy (ART), but loss to follow up (LTFU) can be substantial. We analyzed mortality in children retained in care and in all ...

Virologic failure and second-line antiretroviral therapy in children in South Africa-the IeDEA Southern Africa collaboration

Davies M.-A.; Moultrie H.; Eley B.; Rabie H.; Van Cutsem G.; Giddy J.; Wood R.; Technau K.; Keiser O.; Egger M.; Boulle A. (2011)

Background: With expanding pediatric antiretroviral therapy (ART) access, children will begin to experience treatment failure and require second-line therapy. We evaluated the probability and determinants of virologic ...

Pyridoxal-5-phosphate plasma concentrations in children receiving tuberculosis chemotherapy including isoniazid

Cilliers K.; Labadarios D.; Schaaf H.S.; Willemse M.; Maritz J.S.; Werely C.J.; Hussey G.; Donald P.R. (2010)

Aim: Little is known about pyridoxine nutriture of children treated with isoniazid (INH) regimens. This study documents plasma pyridoxal 5′-phosphate (PLP) concentrations in children, HIV-infected and HIV-uninfected, ...

Cytomorphological patterns of M. bovis BCG and M. tuberculosis on fine needle aspiration biopsies: Does HIV make a difference?

Schubert P.T.; Cotton M.F.; Wright C.A. (2011)

To determine if fine needle aspiration (FNAB) of mycobacterial lymphadenopathy can differentiate infection with M. bovis BCG (BCG) from M. tuberculosis (TB) and whether HIV status affects discriminatory cytological features. ...

High heritability of antimycobacterial immunity in an area of hyperendemicity for tuberculosis disease

Cobat, A.; Gallant, C. J.; Simkin, L.; Black, G. F.; Stanley, K.; Hughes, J.; Mark, Doherty T.; Hanekom, W. A.; Eley, B.; Beyers, N.; Jais, J.-P.; Van Helden, P.; Abel, L.; Hoal, E. G.; Alcais, A.; Schurr, E. (2010)

Human antimycobacterial immunity is a critical component of tuberculosis (TB) pathogenesis that is often used to infer the presence of TB infection. We report high heritability (>50%) for in vitro secretion of tumor ...

HIV prevention through sport: The case of the Mathare Youth Sport Association in Kenya

Delva W.; Michielsen K.; Meulders B.; Groeninck S.; Wasonga E.; Ajwang P.; Temmerman M.; Vanreusel B. (2010)

Sport has become a popular tool for HIV prevention, based on claims that it can foster life skills that are necessary to translate knowledge, attitudes and behavioural intentions into actual behaviour. Empirical evidence ...

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