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Improvement in mycobacterial yield and reduced time to detection in pediatric samples by use of a nutrient broth growth supplement

Brittle W.; Marais B.J.; Hesseling A.C.; Schaaf H.S.; Kidd M.; Wasserman E.; Botha T. (2009)

There is an urgent need to improve the methods used for the bacteriological diagnosis of childhood mycobacterial disease. This study compared the mycobacterial yields and the times to detection (in days) of mycobacteria ...

Diagnosing mycobacterial lymphadenitis in children using fine needle aspiration biopsy: Cytomorphology, ZN staining and autofluorescence-making more of less

Wright C.A.; Van Der Burg M.; Geiger D.; Noordzij J.G.; Burgess S.M.; Marais B.J. (2008)

Although the incidence of TB has stabilized or declined in most world regions, it is increasing in Africa, Southeast Asia, and the Eastern Mediterranean, fuelled by the HIV pandemic. More than 4,000 people died daily from ...

Opportunities for chemoprophylaxis in children with culture-confirmed tuberculosis

Du Preez K.; Hesseling A.C.; Mandalakas A.M.; Marais B.J.; Schaaf H.S. (2011)

Childhood drug-resistant tuberculosis in the Western Cape Province of South Africa

Schaaf H.S.; Marais B.J.; Hesseling A.C.; Gie R.P.; Beyers N.; Donald P.R. (2006)

Aim: Continued surveillance of drug resistance amongst children presenting with culture-confirmed tuberculosis to a tertiary care hospital and to community clinics. Methods: Drug susceptibility testing for isoniazid and ...

Fine-needle aspiration biopsy: A fi rst-line diagnostic procedure in paediatric tuberculosis suspects with peripheral lymphadenopathy?

Wright C.A.; Hesseling A.C.; Bamford C.; Burgess S.M.; Warren R.; Marais B.J. (2009)

OBJECTIVE: To evaluate the diagnostic yield and time to diagnosis of fi ne-needle aspiration biopsy (FNAB) vs. routine respiratory specimens collected from children with a palpable peripheral lymph node mass and symptoms ...

Beijing and Haarlem genotypes are overrepresented among children with drug-resistant tuberculosis in the Western Cape province of South Africa

Marais B.J.; Victor T.C.; Hesseling A.C.; Barnard M.; Jordaan A.; Brittle W.; Reuter H.; Beyers N.; Van Helden P.D.; Warren R.M.; Schaaf H.S. (2006)

Drug resistance among children with culture-confirmed tuberculosis (TB) provides an accurate measure of transmitted drug resistance within the community. We describe the genotype diversity in children with culture-confirmed ...

A critical look at the diagnostic value of culture-confirmation in childhood tuberculosis

Engelbrecht A.L.; Marais B.J.; Donald P.R.; Schaaf H.S. (2006)

Objectives: To describe the clinical presentation, delay in diagnosis and treatment initiation, and outcome of culture-confirmed childhood tuberculosis. Methods: Retrospective study of children < 13 years of age at Tygerberg ...

Rise in rifampicin-monoresistant tuberculosis in Western Cape, South Africa

Mukinda F.K.; Theron D.; Van Der Spuy G.D.; Jacobson K.R.; Roscher M.; Streicher E.M.; Musekiwa A.; Coetzee G.J.; Victor T.C.; Marais B.J.; Nachega J.B.; Warren R.M.; Schaaf H.S. (2012)

SETTING: Brewelskloof Hospital, Western Cape, South Africa. OBJECTIVES: To verify the perceived increase in rifampicin monoresistant tuberculosis (RMR-TB) in the Cape Winelands-Overberg region and to identify potential ...

Absence of an association between Mycobacterium tuberculosis genotype and clinical features in children with tuberculous meningitis

Maree F.; Hesseling A.C.; Schaaf H.S.; Marais B.J.; Beyers N.; Van Helden P.; Warren R.M.; Schoeman J.F. (2007)

OBJECTIVES: Animal studies point to increased virulence of certain mycobacterial strains, notably those of the Beijing genotype. There are limited data on mycobacterial genotypic diversity in children with tuberculous ...

Radiographic signs and symptoms in children treated for tuberculosis: Possible implications for symptom-based screening in resource-limited settings

Marais B.J.; Gie R.P.; Hesseling A.C.; Schaaf H.S.; Enarson D.A.; Beyers N. (2006)

Background: The World Health Organization advises active tracing of children younger than 5 years old in household contact with a sputum smear-positive tuberculosis index case. This study compared radiographic disease ...