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Hepatic toxicity during chemotherapy for severe tuberculous meningitis
(1987)
The possible development of hepatotoxic effects as a result of high dosages of isoniazid, rifampin, pyrazinamide, and ethionamide was assessed in 56 young children (median age, 22 months) treated for severe tuberculous ...
Serial lumbar CSF pressure measurements and cranial computed tomographic findings in childhood tuberculous meningitis
(2000)
Intracranial pressure (ICP) was monitored in 218 consecutive children with hydrocephalus secondary to tuberculous meningitis (TBM). All children underwent cranial computerized tomographic (CT) scanning and continuous lumbar ...
Drug treatment of tuberculosis meningitis in children. A practical guide
(1996)
Treatment must be continued for a minimum of 6 months, but should be extended to 9 or 12 months if rifampicin cannot be used throughout and if pyrazinamide cannot be used for the first 2 months of treatment. Hydrocephalus ...
Pyridoxal-5-phosphate plasma concentrations in children receiving tuberculosis chemotherapy including isoniazid
(2010)
Aim: Little is known about pyridoxine nutriture of children treated with isoniazid (INH) regimens. This study documents plasma pyridoxal 5′-phosphate (PLP) concentrations in children, HIV-infected and HIV-uninfected, ...
Childhood drug-resistant tuberculosis in the Western Cape Province of South Africa
(2006)
Aim: Continued surveillance of drug resistance amongst children presenting with culture-confirmed tuberculosis to a tertiary care hospital and to community clinics. Methods: Drug susceptibility testing for isoniazid and ...
The 5-year outcome of multidrug resistant tuberculosis patients in the Cape Province of South Africa
(1996)
Little is known about the outcome of multidrug resistant (MDR) tuberculosis (TB) in developing countries. In this study, 443 patients with MDR-TB, defined as resistance to two Or more antituberculosis drugs, were identified ...
Prospective evaluation of World Health Organization criteria to assist diagnosis of tuberculosis in children
(1998)
Because of the difficulty in confirming childhood tuberculosis (TB), the World Health Organization (WHO) proposes a hierarchical approach to diagnosis using history and certain clinical features to help to improve the ...
Intensive short course chemotherapy in the management of tuberculous meningitis
(1998)
SETTING: Short course chemotherapy for tuberculous meningitis (TBM) is advocated by several groups, but relatively few children have been so treated and followed up. METHODS: A prospective, observational study of isoniazid ...
Pediatric meningitis in the Western Cape Province of South Africa
(1996)
During the 9 years 1985-1993 a prospective survey of all cases of meningitis in children < 13 years of age presenting to our hospital in the Western Cape Province of South Africa was carried out. Two-thousand-nine-hundre ...
Failure to gain in weight prior to the diagnosis of pulmonary tuberculosis
(1988)
Patterns of weight gain prior to the diagnosis of pulmonary tuberculosis (PTB) in a group of 149 children notified as suffering from PTB were studied. Of 50 children with probable PTB, 33 (66 per cent) were either losing ...