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Analysis for a limited number of gene codons can predict drug resistance of Mycobacterium tuberculosis in a high-incidence community

Van Rie A.; Warren R.; Mshanga I.; Jordaan A.M.; Van Der Spuy G.D.; Richardson M.; Simpson J.; Gie R.P.; Enarson D.A.; Beyers N.; Van Helden P.D.; Victor T.C. (2001)

Correct and rapid diagnosis is essential in the management of multidrug-resistant tuberculosis (MDR-TB). In this population-based study of 61 patients with drug-resistant tuberculosis, we evaluated the frequency of mutations ...

Calculation of the stability of the IS6110 banding pattern in patients with persistent Mycobacterium tuberculosis disease

Warren R.M.; Van der Spuy G.D.; Richardson M.; Beyers N.; Borgdorff M.W.; Behr M.A.; Van Helden P.D. (2002)

The interpretation of molecular epidemiologic data of Mycobacterium tuberculosis infection is dependent on the understanding of the stability and evolutionary characteristics of the DNA fingerprinting marker used to classify ...

Evolution of the IS6110-based restriction fragment length polymorphism pattern during the transmission of Mycobacterium tuberculosis

Warren R.M.; Van der Spuy G.D.; Richardson M.; Beyers N.; Booysen C.; Behr M.A.; Van Helden P.D. (2002)

Interpretation of the molecular epidemiological data of Mycobacterium tuberculosis is dependent on the validity of the assumptions that have been made. It is assumed that the IS6110 banding pattern is sufficiently stable ...

Childhood drug-resistant tuberculosis in the Western Cape Province of South Africa

Schaaf H.S.; Marais B.J.; Hesseling A.C.; Gie R.P.; Beyers N.; Donald P.R. (2006)

Aim: Continued surveillance of drug resistance amongst children presenting with culture-confirmed tuberculosis to a tertiary care hospital and to community clinics. Methods: Drug susceptibility testing for isoniazid and ...

The 5-year outcome of multidrug resistant tuberculosis patients in the Cape Province of South Africa

Schaaf H.S.; Botha P.; Beyers N.; Gie R.P.; Vermeulen H.A.S.; Groenewald P.; Coetzee G.J.; Donald P.R. (1996)

Little is known about the outcome of multidrug resistant (MDR) tuberculosis (TB) in developing countries. In this study, 443 patients with MDR-TB, defined as resistance to two Or more antituberculosis drugs, were identified ...

Beijing and Haarlem genotypes are overrepresented among children with drug-resistant tuberculosis in the Western Cape province of South Africa

Marais B.J.; Victor T.C.; Hesseling A.C.; Barnard M.; Jordaan A.; Brittle W.; Reuter H.; Beyers N.; Van Helden P.D.; Warren R.M.; Schaaf H.S. (2006)

Drug resistance among children with culture-confirmed tuberculosis (TB) provides an accurate measure of transmitted drug resistance within the community. We describe the genotype diversity in children with culture-confirmed ...

Genetic susceptibility to tuberculosis in Africans: A genome-wide scan

Bellamy R.; Beyers N.; McAdam K.P.W.J.; Ruwende C.; Gie R.; Samaai P.; Bester D.; Meyer M.; Corrah T.; Collin M.; Camidge D.R.; Wilkinson D.; Hoal-Van Helden E.; Whittle H.C.; Amos W.; Van Helden P.; Hill A.V.S. (2000)

Human genetic variation is an important determinant of the outcome of infection with Mycobacterium tuberculosis. We have conducted a two-stage genome-wide linkage study to search for regions of the human genome containing ...

Adenylate kinase activity in the cerebrospinal fluid of children with tuberculous meningitis and its relationship to neurological outcome

Carlini S.M.; Beyers N.; Schoeman J.F.; Nel E.D.; Truter E.J.; Donald P.R. (1997)

Cerebrospinal fluid (CSF) adenylate kinase activity was determined in 88 children (mean age 32.6 months) at stage II (n = 40) and stage III (n = 48) tuberculous meningitis (TBM) at, or shortly after, the initiation of ...

Management of children with tuberculosis admitted to a pediatric intensive care unit

Heyns L.; Gie R.P.; Kling S.; Samaai P.; Schaaf H.S.; Beyers N. (1998)

Objectives. To review the incidence, clinical features, ventilatory support and outcome of children with tuberculosis (TB) admitted to a Pediatric Intensive Care Unit (PICU) in a region with an high incidence of TB. Materials ...

Classification of drug-resistant tuberculosis in an epidemic area

Van Rie A.; Warren R.; Richardson M.; Gie R.P.; Enarson D.A.; Beyers N.; Van Helden P.D. (2000)

Background: Traditionally, patients with drug-resistant tuberculosis are classified as having acquired drug-resistant or primary drug-resistant disease on the basis of a history of previous tuberculosis treatment. Only ...