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Investigating the Human-M. tuberculosis interactome to identify the host targets of ESAT-6 and other mycobacterial antigens
(Stellenbosch : Stellenbosch University, 2012-12)
ENGLISH ABSTRACT: The causative agent of human tuberculosis, Mycobacterium tuberculosis, is an intracellular
pathogen that secretes virulence factors, namely ESAT-6 and CFP-10, as substrates of the
ESX-1 secretion system. ...
The contribution of the placenta to the diagnosis of congenital tuberculosis
(Stellenbosch : Stellenbosch University, 2014-04)
ENGLISH ABSTRACT: The aim of this pilot project was to determine whether mothers with laboratory confirmed or clinically
suspected tuberculosis (TB)
had evidence of TB in the placenta. A secondary objective was to ...
Identification of mechanisms regulating the intra cellular concentration of rifampicin in Mycobacterium Tuberculosis
(Stellenbosch : Stellenbosch University, 2013-03)
ENGLISH ABSTRACT: Rifampicin resistance in clinical isolates of Mycobacterium tuberculosis develops through selection of bacterial variants harbouring mutations in the rpoB gene. These mutations infer a fitness-cost in the ...
Regulation of efflux in rifampicin resistant mutants of Mycobacterium tuberculosis
(Stellenbosch : Stellenbosch University, 2013-03)
ENGLISH ABSTRACT: Multidrug resistant tuberculosis (MDR-TB), defined as having resistance to at least the first-line drugs, isoniazid and rifampicin (RIF), is a global health problem. Mutations in the rpoB gene, encoding ...
Understanding the evolution and function of the mycobacterial Type VII ESX secretion systems (T7SSs) and their substrates
(Stellenbosch : Stellenbosch University, 2013-03)
ENGLISH ABSTRACT: Mycobacterium tuberculosis, the causative agent of tuberculosis disease, contains five copies of the ESAT-6
gene cluster, each encoding a dedicated ESX protein secretion system which has been defined as ...
Diagnostic utility of the line probe assay for the detection of drug resistance in Mycobacterium tuberculosis
(Stellenbosch : Stellenbosch University, 2013-03)
ENGLISH ABSTRACT: The epidemic levels of drug-resistant tuberculosis (DR-TB) in high-burden countries such as South Africa, which is currently ranked as third highest in the world, is the result of a synergistic relationship ...