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Mycobacterium tuberculosis : genetic and phenotypic comparison
(Stellenbosch : Stellenbosch University, 2002-03)
ENGLISH ABSTRACT: This study exploits the Mycobacterium tuberculosis H37Rv genome sequence data in
the context of M. tuberculosis clinical isolates, to elucidate genetic variation, and examine the
phenotypic and molecular ...
The regulation and function of the ESAT-6 gene cluster operons of Mycobacterium tuberculosis
(Stellenbosch : University of Stellenbosch, 2006-12)
The ESAT-6 gene cluster regions are duplicated 5 times in the genome of Mycobacterium tuberculosis. ESAT-6 gene cluster region 1 is the most frequently studied region as it contains RD1 (region of difference 1). RD1 is a ...
The trafficking of the Mycobacterium tuberculosis PE and PPE proteins
(Stellenbosch : University of Stellenbosch, 2007-12)
The expansion of the Mycobacterium tuberculosis PE and PPE gene families seems to be linked to that
of the immunologically-important ESAT-6 (esx) gene clusters secretion system, as the ancestral
members of these families ...
The mycosins, a family of secreted subtilisin-like serine proteases associated with the immunologically-important ESAT-6 gene clusters of Mycobacterium tuberculosis
(Stellenbosch : Stellenbosch University, 2002-12)
ENGLISH ABSTRACT: Pathogenic organisms frequently utilize proteases to perform specific functions related to
virulence. There is little information regarding the role of proteolysis in Mycobacterium tuberculosis
and no ...
Resistance to first line anti-TB drugs by gene mutation and gene modulation
(Stellenbosch : University of Stellenbosch, 2009-03)
Investigation of the ESX-4 secretion system interactome of Mycobacterium tuberculosis
(Stellenbosch : University of Stellenbosch, 2010-12)
ENGLISH ABSTRACT: The genome of the pathogen Mycobacterium tuberculosis contains five copies of the ESAT-6
(ESX) gene cluster region, which encodes for a novel type VII secretion system. These gene
cluster regions, which ...
Investigating the localisation of the ESX-3 secretion system in Mycobacterium smegmatis
(Stellenbosch : Stellenbosch University, 2012-12)
ENGLISH ABSTRACT: Mycobacterium tuberculosis is a pathogenic organism that infects a third of the world’s population and
causes approximately 2 million deaths per year. Extensive research has been done on this pathogen,
however ...