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The effect of 5'-aminoimidazole-4-carboxamide ribonucleoside (AICAR) and 5'-aminoimidazole-4-carboxamide-ribonucleoside-phosphate (ZMP) on myocardial glucose uptake
(Stellenbosch : Stellenbosch University, 2005-03)
ENGLISH ABSTRACT: Introduction: Exercise increases skeletal muscle glucose uptake via AMP-activated
protein kinase (AMPK) activation and GLUT4 translocation from cytosol to cell
membrane. It also promotes glucose ...
The role of melatonin in cardioprotection : an investigation into the mechanisms involved in glucose homeostasis, microvascular endothelial function and mitochondrial function in normal and insulin resistant states
(Stellenbosch : Stellenbosch University, 2014-04)
ENGLISH ABSTRACT: Introduction:
The cardioprotective actions of the hormone melatonin against myocardial ischaemiareperfusion
injury (IRI) are well-established. It has recently been shown to prevent the harmful
effects ...
The impact of activation of the renin-angiotensin system in the development of insulin resistance in experimental models of obesity
(Stellenbosch : University of Stellenbosch, 2009-03)
Insulin stimulates the production of nitric oxide (NO) in endothelial cells and cardiac
myocytes by a signalling pathway that involves the insulin receptor substrate (IRS)-1,
phosphatidylinositol-3-kinase and protein ...
Exposure of cardiac microvascular endothelial cells to harmful stimuli : a study of the cellular responses and mechanisms
(Stellenbosch : Stellenbosch University, 2014-04)
ENGLISH ABSTRACT: Exposure to harmful stimuli can render vascular endothelial cells dysfunctional, characterised by
reduced nitric oxide (NO) bioavailibility. Endothelial dysfunction (ED) is a reversible precursor ...
A critical analysis of mitochondrial functioning and associated proteins in obesity-related cardiomyopathy
(Stellenbosch : Stellenbosch University, 2013-03)
ENGLISH ABSTRACT: INTRODUCTION: The mechanism behind obesity-related cardiomyopathies is at present not completely known, however, cardiac insulin resistance has been implicated as one of the main arbitrators of obesity-related ...