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Elucidation of the substrates of mycosin 3, an essential protease of Mycobacterium tuberculosis
(Stellenbosch : University of Stellenbosch, 2011-03)
ENGLISH ABSTRACT: Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), infects one third of the
world’s population and kills 1.7 million people per year. The increasing prevalence of multi- and
extensively ...
Investigating the Human-M. tuberculosis interactome to identify the host targets of ESAT-6 and other mycobacterial antigens
(Stellenbosch : Stellenbosch University, 2012-12)
ENGLISH ABSTRACT: The causative agent of human tuberculosis, Mycobacterium tuberculosis, is an intracellular
pathogen that secretes virulence factors, namely ESAT-6 and CFP-10, as substrates of the
ESX-1 secretion system. ...
Understanding the evolution and function of the mycobacterial Type VII ESX secretion systems (T7SSs) and their substrates
(Stellenbosch : Stellenbosch University, 2013-03)
ENGLISH ABSTRACT: Mycobacterium tuberculosis, the causative agent of tuberculosis disease, contains five copies of the ESAT-6
gene cluster, each encoding a dedicated ESX protein secretion system which has been defined as ...