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The regulation and function of the ESAT-6 gene cluster operons of Mycobacterium tuberculosis
(Stellenbosch : University of Stellenbosch, 2006-12)
The ESAT-6 gene cluster regions are duplicated 5 times in the genome of Mycobacterium tuberculosis. ESAT-6 gene cluster region 1 is the most frequently studied region as it contains RD1 (region of difference 1). RD1 is a ...
The trafficking of the Mycobacterium tuberculosis PE and PPE proteins
(Stellenbosch : University of Stellenbosch, 2007-12)
The expansion of the Mycobacterium tuberculosis PE and PPE gene families seems to be linked to that
of the immunologically-important ESAT-6 (esx) gene clusters secretion system, as the ancestral
members of these families ...
Investigation of the ESX-4 secretion system interactome of Mycobacterium tuberculosis
(Stellenbosch : University of Stellenbosch, 2010-12)
ENGLISH ABSTRACT: The genome of the pathogen Mycobacterium tuberculosis contains five copies of the ESAT-6
(ESX) gene cluster region, which encodes for a novel type VII secretion system. These gene
cluster regions, which ...
Investigating the localisation of the ESX-3 secretion system in Mycobacterium smegmatis
(Stellenbosch : Stellenbosch University, 2012-12)
ENGLISH ABSTRACT: Mycobacterium tuberculosis is a pathogenic organism that infects a third of the world’s population and
causes approximately 2 million deaths per year. Extensive research has been done on this pathogen,
however ...