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A pathologic role for angiotensin II and endothelin-1 in cardiac remodelling and ischaemia and reperfusion injury in a rat model of the metabolic syndrome
(Stellenbosch : University of Stellenbosch, 2006-03)
Introduction: Obesity, which is implicated in the development of the metabolic
syndrome (MS) is reaching epidemic proportions worldwide. MS significantly
increases the risk of developing cardiovascular disease, which ...
The effect of creatine supplementation on myocardial metabolism and function in sedentary and exercised rats
(Stellenbosch : University of Stellenbosch, 2010-12)
ENGLISH ABSTRACT: Background: There has been a dramatic increase in the use of dietary creatine
supplementation among sports men and women, and by clinicians as a therapeutic
agent in muscular and neurological diseases. ...
The effects of physical and psychological stress on the behaviour and neurochemistry of rats
(Stellenbosch : University of Stellenbosch, 2005-12)
Stress is considered one of the major factors involved in the pathogenesis of affective disorders, for example, direct and indirect exposure to terrorist attacks or being subjected to subtle victimization. There is a long ...
Possible mechanisms for levosimendaninduced cardioprotection
(Stellenbosch : Stellenbosch University, 2008-12)
Background and purpose. To limit ischaemic injury, rapid restoration of coronary
blood flow is required, which will in turn reduce infarct size. However, reperfusion
itself causes myocyte death – a phenomenon termed ...
The effect of CPT-1 inhibition on myocardial function and resistance to ischemia/reperfusion injury in a rodent model of the metabolic syndrome
(Stellenbosch : University of Stellenbosch, 2010-12)
ENGLISH ABSTRACT: Background: Obesity is associated with dyslipidemia, insulin resistance and glucose intolerance and together these components characterise the metabolic syndrome (Dandona et al. 2005). In the state of ...