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Improvement in mycobacterial yield and reduced time to detection in pediatric samples by use of a nutrient broth growth supplement

Brittle W.; Marais B.J.; Hesseling A.C.; Schaaf H.S.; Kidd M.; Wasserman E.; Botha T. (2009)

There is an urgent need to improve the methods used for the bacteriological diagnosis of childhood mycobacterial disease. This study compared the mycobacterial yields and the times to detection (in days) of mycobacteria ...

Opportunities for chemoprophylaxis in children with culture-confirmed tuberculosis

Du Preez K.; Hesseling A.C.; Mandalakas A.M.; Marais B.J.; Schaaf H.S. (2011)

High incidence of tuberculosis among HIV-infected infants: Evidence from a South African population-based study highlights the need for improved tuberculosis control strategies

Hesseling A.C.; Cotton M.F.; Jennings T.; Whitelaw A.; Johnson L.F.; Eley B.; Roux P.; Godfrey-Faussett P.; Schaaf H.S. (2009)

Background. There are limited population-based estimates of tuberculosis incidence among human immunodeficiency virus (HIV)-infected and HIV-uninfected infants aged ≤12 months. We aimed to estimate the population-based ...

Tuberculosis exposure in HIV-exposed infants in a high-prevalence setting

Cotton M.F.; Schaaf H.S.; Lottering G.; Weber H.L.; Coetzee J.; Nachman S. (2008)

Exposure to TB was quantified by screening human immunodeficiency virus (HIV) exposed infants aged 3-4 months for an isoniazid prophylaxis study where tuberculosis (TB) exposure excluded enrolment. Seventy-seven (10.1%, ...

Pyridoxal-5-phosphate plasma concentrations in children receiving tuberculosis chemotherapy including isoniazid

Cilliers K.; Labadarios D.; Schaaf H.S.; Willemse M.; Maritz J.S.; Werely C.J.; Hussey G.; Donald P.R. (2010)

Aim: Little is known about pyridoxine nutriture of children treated with isoniazid (INH) regimens. This study documents plasma pyridoxal 5′-phosphate (PLP) concentrations in children, HIV-infected and HIV-uninfected, ...

Childhood drug-resistant tuberculosis in the Western Cape Province of South Africa

Schaaf H.S.; Marais B.J.; Hesseling A.C.; Gie R.P.; Beyers N.; Donald P.R. (2006)

Aim: Continued surveillance of drug resistance amongst children presenting with culture-confirmed tuberculosis to a tertiary care hospital and to community clinics. Methods: Drug susceptibility testing for isoniazid and ...

Diagnostic aspects of cervical lymphadenopathy in children in the developing world: A study of 1,877 surgical specimens

Moore S.W.; Schneider J.W.; Schaaf H.S. (2003)

Chronic cervical lymphadenopathy is a common clinical problem frequently requiring surgical biopsy. To evaluate the characteristics of surgically excised cervical lymph nodes (LN) in children in a developing country, we ...

The 5-year outcome of multidrug resistant tuberculosis patients in the Cape Province of South Africa

Schaaf H.S.; Botha P.; Beyers N.; Gie R.P.; Vermeulen H.A.S.; Groenewald P.; Coetzee G.J.; Donald P.R. (1996)

Little is known about the outcome of multidrug resistant (MDR) tuberculosis (TB) in developing countries. In this study, 443 patients with MDR-TB, defined as resistance to two Or more antituberculosis drugs, were identified ...

Prospective evaluation of World Health Organization criteria to assist diagnosis of tuberculosis in children

Houwert K.A.F.; Borggreven P.A.; Schaaf H.S.; Nel E.; Donald P.R.; Stolk J. (1998)

Because of the difficulty in confirming childhood tuberculosis (TB), the World Health Organization (WHO) proposes a hierarchical approach to diagnosis using history and certain clinical features to help to improve the ...

Beijing and Haarlem genotypes are overrepresented among children with drug-resistant tuberculosis in the Western Cape province of South Africa

Marais B.J.; Victor T.C.; Hesseling A.C.; Barnard M.; Jordaan A.; Brittle W.; Reuter H.; Beyers N.; Van Helden P.D.; Warren R.M.; Schaaf H.S. (2006)

Drug resistance among children with culture-confirmed tuberculosis (TB) provides an accurate measure of transmitted drug resistance within the community. We describe the genotype diversity in children with culture-confirmed ...