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The burden of childhood tuberculosis: A public health perspective

Marais B.J.; Obihara C.C.; Warren R.M.; Schaaf H.S.; Gie R.P.; Donald P.R. (2005)

The burden of childhood tuberculosis (TB) reflects recent transmission within a community and the level of TB control achieved within the adult (maintenance host) population. Children contribute little to the maintenance ...

Beijing and Haarlem genotypes are overrepresented among children with drug-resistant tuberculosis in the Western Cape province of South Africa

Marais B.J.; Victor T.C.; Hesseling A.C.; Barnard M.; Jordaan A.; Brittle W.; Reuter H.; Beyers N.; Van Helden P.D.; Warren R.M.; Schaaf H.S. (2006)

Drug resistance among children with culture-confirmed tuberculosis (TB) provides an accurate measure of transmitted drug resistance within the community. We describe the genotype diversity in children with culture-confirmed ...

Mycobacterium tuberculosis transmission is not related to household genotype in a setting of high endemicity

Marais B.J.; Hesseling A.C.; Schaaf H.S.; Gie R.P.; Van Helden P.D.; Warren R.M. (2009)

Among the different strains of Mycobacterium tuberculosis, Beijing has been identified as an emerging genotype. Enhanced transmissibility provides a potential mechanism for genotype selection. This study evaluated whether ...

Mycobacterial genotype is associated with disease phenotype in children

Hesseling A.C.; Marais B.J.; Kirchner H.L.; Mandalakas A.M.; Brittle W.; Victor T.C.; Warren R.M.; Schaaf H.S. (2010)

OBJECTIVE: To investigate the association between mycobacterial genotype and disease phenotype in children. METHODS: We describe hospitalised children diagnosed with culture-confirmed tuberculosis (TB) in South Africa, a ...

Rise in rifampicin-monoresistant tuberculosis in Western Cape, South Africa

Mukinda F.K.; Theron D.; Van Der Spuy G.D.; Jacobson K.R.; Roscher M.; Streicher E.M.; Musekiwa A.; Coetzee G.J.; Victor T.C.; Marais B.J.; Nachega J.B.; Warren R.M.; Schaaf H.S. (2012)

SETTING: Brewelskloof Hospital, Western Cape, South Africa. OBJECTIVES: To verify the perceived increase in rifampicin monoresistant tuberculosis (RMR-TB) in the Cape Winelands-Overberg region and to identify potential ...

Resistant Mycobacterium bovis Bacillus Calmette-Guérin Disease: Implications for Management of Bacillus Calmette-Guérin Disease in Human Immunodeficiency Virus-Infected Children

Hesseling A.C.; Schaaf H.S.; Victor T.; Beyers N.; Marais B.J.; Cotton M.F.; Wiid I.; Gie R.P.; Van Helden P.; Warren R.M. (2004)

Guidelines for the diagnosis and management of Bacillus Calmette-Guérin (BCG) disease in children are lacking, and there are limited data on drug resistance of Mycobacterium bovis BCG. A 6-month-old HIV-infected infant ...

Recurrent culture-confirmed tuberculosis in human immunodeficiency virus-infected children

Schaaf H.S.; Krook S.; Hollemans D.W.; Warren R.M.; Donald P.R.; Hesseling A.C. (2005)

Introduction: Recurrent tuberculosis (TB) is more common among human immunodeficiency virus (HIV)-infected than HIV-uninfected adults. There are limited data regarding recurrence of TB in children. Objective: To determine ...

Absence of an association between Mycobacterium tuberculosis genotype and clinical features in children with tuberculous meningitis

Maree F.; Hesseling A.C.; Schaaf H.S.; Marais B.J.; Beyers N.; Van Helden P.; Warren R.M.; Schoeman J.F. (2007)

OBJECTIVES: Animal studies point to increased virulence of certain mycobacterial strains, notably those of the Beijing genotype. There are limited data on mycobacterial genotypic diversity in children with tuberculous ...