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Genome and MIC stability in Mycobacterium tuberculosis and indications for continuation of use of isoniazid in multidrug-resistant tuberculosis

Victor T.C.; Warren R.; Butt J.L.; Jordaan A.M.; Felix J.V.; Venter A.; Sirgel F.A.; Schaaf H.S.; Donald P.R.; Richardson M.; Cynamon M.H.; Van Helden P.D. (1997)

Mycobacterium tuberculosis strains resistant to two or more of the first line antituberculosis drugs (MDR) are a serious threat to successful tuberculosis control programmes. For this retrospective study, 85 follow-up drug ...

An outbreak of drug-resistant tuberculosis caused by a Beijing strain in the Western Cape, South Africa

Johnson R.; Warren R.; Strauss O.J.; Jordaan A.M.; Falmer A.A.; Beyers N.; Schaaf H.S.; Murray M.; Cloete K.; Van Helden P.D.; Victor T.C. (2006)

During October 2005, four children in a school in Cape Town were identified with multidrug-resistant tuberculosis (MDR-TB). Genetic analysis confirmed that these isolates belonged to a single cluster (Beijing cluster 220) ...

Adult-to-child transmission of tuberculosis: Household or community contact?

Schaaf H.S.; Michaelis I.A.; Richardson M.; Booysen C.N.; Gie R.P.; Warren R.; Van Helden P.D.; Beyers N. (2003)

SETTING: If a child develops tuberculosis, it is assumed that the source was an adult infectious case, usually living in the same house. Restriction fragment length polymorphism (RFLP) was used in this study to establish ...

Unexpectedly high strain diversity of Mycobacterium tuberculosis in a high-incidence community

Warren R.; Hauman J.; Beyers N.; Richardson M.; Schaaf H.S.; Donald P.; Van Helden P. (Health & Medical Publishing Group, 1996)

Objective. To characterise Mycobacterium tuberculosis strains present in a community experiencing an epidemic, in order to establish whether a high rate of transmission results in low strain diversity. Design. Sputum ...