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Ethionamide cross-and co-resistance in children with isoniazid-resistant tuberculosis

Schaaf H.S.; Victor T.C.; Venter A.; Brittle W.; Jordaan A.M.; Hesseling A.C.; Marais B.J.; Van Helden P.D.; Donald P.R. (2009)

BACKGROUND: Ethionamide (ETH) is a structural analogue of isoniazid (INH). Both are pro-drugs requiring activation by separate and common enzyme pathways, which could lead to co-and/or cross-resistance. OBJECTIVE: To ...

Minimal inhibitory concentration of isoniazid in isoniazid-resistant Mycobacterium tuberculosis isolates from children

Schaaf H.S.; Victor T.C.; Engelke E.; Brittle W.; Marais B.J.; Hesseling A.C.; Van Helden P.D.; Donald P.R. (2006)

The aim of the study presented here was to determine the minimal inhibitory concentration of isoniazid for strains of isoniazid-resistant or multidrug-resistant Mycobacterium tuberculosis isolated from children in the ...

Impact of drug resistance on clinical outcome in children with tuberculous meningitis

Seddon J.A.; Visser D.H.; Bartens M.; Jordaan A.M.; Victor T.C.; Van Furth A.M.; Schoeman J.F.; Schaaf H.S. (2012)

Background: Tuberculous meningitis (TBM) is associated with delayed diagnosis and poor outcome in children. This study investigated the impact of drug resistance on clinical outcome in children with TBM. Methods: All ...

Beijing and Haarlem genotypes are overrepresented among children with drug-resistant tuberculosis in the Western Cape province of South Africa

Marais B.J.; Victor T.C.; Hesseling A.C.; Barnard M.; Jordaan A.; Brittle W.; Reuter H.; Beyers N.; Van Helden P.D.; Warren R.M.; Schaaf H.S. (2006)

Drug resistance among children with culture-confirmed tuberculosis (TB) provides an accurate measure of transmitted drug resistance within the community. We describe the genotype diversity in children with culture-confirmed ...

Genome and MIC stability in Mycobacterium tuberculosis and indications for continuation of use of isoniazid in multidrug-resistant tuberculosis

Victor T.C.; Warren R.; Butt J.L.; Jordaan A.M.; Felix J.V.; Venter A.; Sirgel F.A.; Schaaf H.S.; Donald P.R.; Richardson M.; Cynamon M.H.; Van Helden P.D. (1997)

Mycobacterium tuberculosis strains resistant to two or more of the first line antituberculosis drugs (MDR) are a serious threat to successful tuberculosis control programmes. For this retrospective study, 85 follow-up drug ...

An outbreak of drug-resistant tuberculosis caused by a Beijing strain in the Western Cape, South Africa

Johnson R.; Warren R.; Strauss O.J.; Jordaan A.M.; Falmer A.A.; Beyers N.; Schaaf H.S.; Murray M.; Cloete K.; Van Helden P.D.; Victor T.C. (2006)

During October 2005, four children in a school in Cape Town were identified with multidrug-resistant tuberculosis (MDR-TB). Genetic analysis confirmed that these isolates belonged to a single cluster (Beijing cluster 220) ...

Mycobacterial genotype is associated with disease phenotype in children

Hesseling A.C.; Marais B.J.; Kirchner H.L.; Mandalakas A.M.; Brittle W.; Victor T.C.; Warren R.M.; Schaaf H.S. (2010)

OBJECTIVE: To investigate the association between mycobacterial genotype and disease phenotype in children. METHODS: We describe hospitalised children diagnosed with culture-confirmed tuberculosis (TB) in South Africa, a ...

Discordant drug susceptibility for mycobacterium tuberculosis within families

Seddon J.A.; Jordaan A.M.; Victor T.C.; Schaaf H.S. (2012)

Children with presumed tuberculosis who are in contact with a multidrug-resistant source case should be treated according to the drug susceptibility of the source case's isolate. However, it is important to obtain a ...

High prevalence of drug resistance amongst HIV-exposed and -infected children in a tuberculosis prevention trial

Hesseling A.C.; Kim S.; Madhi S.; Nachman S.; Schaaf H.S.; Violari A.; Victor T.C.; McSherry G.; Mitchell C.; Cotton M.F. (2012)

An emergence of drug-resistant tuberculosis (DR-TB) in settings affected by human immunodeficiency virus (HIV) and tuberculosis (TB) has been observed. We investigated the prevalence of DR-TB in P1041, a multicentred, ...

Rise in rifampicin-monoresistant tuberculosis in Western Cape, South Africa

Mukinda F.K.; Theron D.; Van Der Spuy G.D.; Jacobson K.R.; Roscher M.; Streicher E.M.; Musekiwa A.; Coetzee G.J.; Victor T.C.; Marais B.J.; Nachega J.B.; Warren R.M.; Schaaf H.S. (2012)

SETTING: Brewelskloof Hospital, Western Cape, South Africa. OBJECTIVES: To verify the perceived increase in rifampicin monoresistant tuberculosis (RMR-TB) in the Cape Winelands-Overberg region and to identify potential ...