Search
Now showing items 1-7 of 7
Impact of drug resistance on clinical outcome in children with tuberculous meningitis
(2012)
Background: Tuberculous meningitis (TBM) is associated with delayed diagnosis and poor outcome in children. This study investigated the impact of drug resistance on clinical outcome in children with TBM. Methods: All ...
Management of children exposed to multidrug-resistant Mycobacterium tuberculosis
(2012)
Children exposed to multidrug-resistant (MDR) Mycobacterium tuberculosis are at risk of developing MDR tuberculosis. Where treatment is available, it is lengthy, expensive, and associated with poor adherence and notable ...
Treatment outcomes for children with multidrug-resistant tuberculosis: A systematic review and meta-analysis
(2012)
Background: Paediatric multidrug-resistant (MDR) tuberculosis is a public health challenge of growing concern, accounting for an estimated 15% of all global cases of MDR tuberculosis. Clinical management is especially ...
Discordant drug susceptibility for mycobacterium tuberculosis within families
(2012)
Children with presumed tuberculosis who are in contact with a multidrug-resistant source case should be treated according to the drug susceptibility of the source case's isolate. However, it is important to obtain a ...
The evolving epidemic of drug-resistant tuberculosis among children in Cape Town, South Africa
(2012)
SETTING: Tygerberg Children's Hospital, Cape Town, South Africa. OBJECTIVE: To determine the prevalence and trend of drug resistance and human immunodeficiency virus (HIV) co-infection among children with culture-confirmed ...
Second-line antituberculosis drugs: Current knowledge, recent research findings and controversies
(2011)
The treatment of drug-resistant tuberculosis (TB) necessitates the use of drugs that are poorly understood, less efficacious and often associated with more adverse effects than those used to treat drugsusceptible TB. Many ...