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Pyrazinamide plasma concentrations in young children with tuberculosis
(2011)
Pyrazinamide plasma concentrations were determined in 34 children (median age, 3.32 years) 1 month after commencing antituberculosis treatment. The median (interquartile range) peak concentration was 30.7 (25.5, 35.0) mg/L ...
Tuberculosis presenting in the neonatal periodd
(1989)
Tuberculosis presenting during the neonatal period is uncommon, but does occur and may prove fatal if not diagnosed in a timely manner. We describe four such cases and draw attention to urogenital tuberculosis in the mother ...
Pyridoxal-5-phosphate plasma concentrations in children receiving tuberculosis chemotherapy including isoniazid
(2010)
Aim: Little is known about pyridoxine nutriture of children treated with isoniazid (INH) regimens. This study documents plasma pyridoxal 5′-phosphate (PLP) concentrations in children, HIV-infected and HIV-uninfected, ...
Childhood drug-resistant tuberculosis in the Western Cape Province of South Africa
(2006)
Aim: Continued surveillance of drug resistance amongst children presenting with culture-confirmed tuberculosis to a tertiary care hospital and to community clinics. Methods: Drug susceptibility testing for isoniazid and ...
Nosocomial infections in HIV-infected and HIV-uninfected children hospitalised for tuberculosis
(2007)
Background: The interaction between tuberculosis and HIV-infected infection is well known and is responsible for the increase in the incidence of tuberculosis (TB) in sub-Saharan Africa over the last decade. This places a ...
Ethionamide cross-and co-resistance in children with isoniazid-resistant tuberculosis
(2009)
BACKGROUND: Ethionamide (ETH) is a structural analogue of isoniazid (INH). Both are pro-drugs requiring activation by separate and common enzyme pathways, which could lead to co-and/or cross-resistance. OBJECTIVE: To ...
Minimal inhibitory concentration of isoniazid in isoniazid-resistant Mycobacterium tuberculosis isolates from children
(2006)
The aim of the study presented here was to determine the minimal inhibitory concentration of isoniazid for strains of isoniazid-resistant or multidrug-resistant Mycobacterium tuberculosis isolated from children in the ...
Primary drug-resistant tuberculosis in children
(2000)
SETTING: The Western Cape Province of South Africa, an area with a high tuberculosis (TB) incidence where initial isoniazid (INH) resistance and multidrug resistance (MDR) among adults was 3.9% and 1.1%, respectively, ...
TB contact screening: Which way to go?
(2009)
[No abstract available]
A proposed comprehensive classification of tuberculosis disease severity in children
(2012)
Background: Tuberculosis (TB) in children has conventionally been classified as pulmonary TB (PTB) and extrapulmonary TB (EPTB) disease, including disseminated TB (TB meningitis and miliary disease). There is no existing ...