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Improvement in mycobacterial yield and reduced time to detection in pediatric samples by use of a nutrient broth growth supplement

Brittle W.; Marais B.J.; Hesseling A.C.; Schaaf H.S.; Kidd M.; Wasserman E.; Botha T. (2009)

There is an urgent need to improve the methods used for the bacteriological diagnosis of childhood mycobacterial disease. This study compared the mycobacterial yields and the times to detection (in days) of mycobacteria ...

Ethionamide cross-and co-resistance in children with isoniazid-resistant tuberculosis

Schaaf H.S.; Victor T.C.; Venter A.; Brittle W.; Jordaan A.M.; Hesseling A.C.; Marais B.J.; Van Helden P.D.; Donald P.R. (2009)

BACKGROUND: Ethionamide (ETH) is a structural analogue of isoniazid (INH). Both are pro-drugs requiring activation by separate and common enzyme pathways, which could lead to co-and/or cross-resistance. OBJECTIVE: To ...

Minimal inhibitory concentration of isoniazid in isoniazid-resistant Mycobacterium tuberculosis isolates from children

Schaaf H.S.; Victor T.C.; Engelke E.; Brittle W.; Marais B.J.; Hesseling A.C.; Van Helden P.D.; Donald P.R. (2006)

The aim of the study presented here was to determine the minimal inhibitory concentration of isoniazid for strains of isoniazid-resistant or multidrug-resistant Mycobacterium tuberculosis isolated from children in the ...

Beijing and Haarlem genotypes are overrepresented among children with drug-resistant tuberculosis in the Western Cape province of South Africa

Marais B.J.; Victor T.C.; Hesseling A.C.; Barnard M.; Jordaan A.; Brittle W.; Reuter H.; Beyers N.; Van Helden P.D.; Warren R.M.; Schaaf H.S. (2006)

Drug resistance among children with culture-confirmed tuberculosis (TB) provides an accurate measure of transmitted drug resistance within the community. We describe the genotype diversity in children with culture-confirmed ...

Mycobacterial genotype is associated with disease phenotype in children

Hesseling A.C.; Marais B.J.; Kirchner H.L.; Mandalakas A.M.; Brittle W.; Victor T.C.; Warren R.M.; Schaaf H.S. (2010)

OBJECTIVE: To investigate the association between mycobacterial genotype and disease phenotype in children. METHODS: We describe hospitalised children diagnosed with culture-confirmed tuberculosis (TB) in South Africa, a ...